Horm Metab Res 2023; 55(01): 59-64
DOI: 10.1055/a-1973-7255
Original Article: Endocrine Care

Predictive Value of Inflammatory Cytokines in Early Pregnancy for Liver Dysfunction in Pregnant Women with Hepatitis B

Wei Wang
1   Department of Science and Education, Shijiazhuang Maternity and Child Healthcare Hospital, Shijiazhuang, China
Hongyan Jia
2   Department of Infection Control Division, Shijiazhuang Maternity and Child Healthcare Hospital, Shijiazhuang, China
Yue Wang
3   Department of Internal Medicine, Shijiazhuang Third Hospital, Shijiazhuang, China
Weize Sun
4   Department of Obstetrics and Gynecology, Ningjin County Maternity and Child Healthcare Hospital, Xingtai, China
Can Yang
5   Department of Internal Medicine, Shijiazhuang Maternity and Child Healthcare Hospital, Shijiazhuang, China
› Author Affiliations
Funding Information Scientific Research Fund of Hebei Provincial Health and Family Planning Commission — 20222619


The purpose of this study is to explore the predictive value of cytokine levels in the first trimester of pregnancy on abnormal liver function of pregnant women with hepatitis B in the third trimester of pregnancy. A total of 111 pregnant women with HBV infection at 12 weeks gestation participated in the study. The levels of IL-6, IL-8, TNF-α in peripheral blood of the patients and liver function indexes were detected. Subsequently, the pregnant women were followed up, and the liver function was detected at 36 weeks of gestation. According to liver function indexes, patients were divided into normal liver function group and abnormal liver function group to determine the correlation between cytokines in early pregnancy and abnormal liver function in late pregnancy. Kaplan–Meier survival curve and multivariate Cox analysis were used to evaluate the predictive value of cytokines for liver dysfunction. At 12 weeks of gestation, cytokine levels in the normal liver function group were significantly lower than that in the abnormal liver function group. Kaplan–Meier survival analysis showed that the increased IL-6 level was associated with abnormal liver function in late pregnancy. Multivariate Cox regression analysis revealed that IL-6 level was an independent predictor of abnormal liver function in patients with normal liver function in the late pregnancy. The high expression level of cytokine IL-6 at 12 weeks of pregnancy has noteworthy predictive significance for the abnormal liver function of hepatitis B pregnant women in third trimester of pregnancy.

These authors contributed equally.

Publication History

Received: 20 June 2022

Accepted after revision: 04 November 2022

Article published online:
29 November 2022

© 2022. Thieme. All rights reserved.

Georg Thieme Verlag KG
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