CC BY-NC-ND 4.0 · J Neurol Surg Rep 2023; 84(01): e1-e5
DOI: 10.1055/a-1996-1283
Case Report

SMARCB1(INI-1)-Deficient Sinonasal Carcinoma: An Evolving Entity

1   Department of Otolaryngology-Head and Neck Surgery, The University of Texas Southwestern Medical Center Ringgold Standard Institution, Dallas, Texas, United States
,
Parker Kenee
1   Department of Otolaryngology-Head and Neck Surgery, The University of Texas Southwestern Medical Center Ringgold Standard Institution, Dallas, Texas, United States
,
Tanner Mitton
1   Department of Otolaryngology-Head and Neck Surgery, The University of Texas Southwestern Medical Center Ringgold Standard Institution, Dallas, Texas, United States
,
Ashleigh Halderman
1   Department of Otolaryngology-Head and Neck Surgery, The University of Texas Southwestern Medical Center Ringgold Standard Institution, Dallas, Texas, United States
› Author Affiliations

Abstract

SMARCB1(INI-1)-deficient sinonasal carcinoma is a rare, poorly differentiated neoplasm with a poor prognosis. Though historically most were identified as sinonasal undifferentiated carcinoma, we now understand it to be a distinct entity. There is currently a general consensus supporting multimodal therapy, though the optimal sequence of surgery, chemotherapy, and radiation has yet to be defined.



Publication History

Received: 15 November 2022

Accepted: 23 November 2022

Accepted Manuscript online:
10 December 2022

Article published online:
16 January 2023

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