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Int J Sports Med 2023; 44(09): 609-617
DOI: 10.1055/a-2035-8192
Review

Estrogen-related Receptor Signaling in Skeletal Muscle Fitness

Danesh Sopariwala
1   Institute of Molecular Medicine, University of Texas John P and Katherine G McGovern Medical School, Houston, United States
,
Hao Nguyen
1   Institute of Molecular Medicine, University of Texas John P and Katherine G McGovern Medical School, Houston, United States
,
Vihang Narkar
1   Institute of Molecular Medicine, University of Texas John P and Katherine G McGovern Medical School, Houston, United States
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Abstract

Skeletal muscle is a highly plastic tissue that can alter its metabolic and contractile features, as well as regenerative potential in response to exercise and other conditions. Multiple signaling factors including metabolites, kinases, receptors, and transcriptional factors have been studied in the regulation of skeletal muscle plasticity. Recently, estrogen-related receptors (ERRs) have emerged as a critical transcriptional hub in control of skeletal muscle homeostasis. ERRα and ERRγ – the two highly expressed ERR sub-types in the muscle respond to various extracellular cues such as exercise, hypoxia, fasting and dietary factors, in turn regulating gene expression in the skeletal muscle. On the other hand, conditions such as diabetes and muscular dystrophy suppress expression of ERRs in the skeletal muscle, likely contributing to disease progression. We highlight key functions of ERRs in the skeletal muscle including the regulation of fiber type, mitochondrial metabolism, vascularization, and regeneration. We also describe how ERRs are regulated in the skeletal muscle, and their interaction with important muscle regulators (e. g. AMPK and PGCs). Finally, we identify critical gaps in our understanding of ERR signaling in the skeletal muscle, and suggest future areas of investigation to advance ERRs as potential targets for function promoting therapeutics in muscle diseases.

Key words

nuclear receptors - transcription - exercise - metabolism - angiogenesis - regeneration


Publication History

Received: 02 September 2022

Accepted: 14 February 2023

Accepted Manuscript online:
14 February 2023

Article published online:
09 May 2023

© 2023. Thieme. All rights reserved.

Georg Thieme Verlag
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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