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CC BY-NC-ND 4.0 · Geburtshilfe Frauenheilkd 2023; 83(08): 1017-1021
DOI: 10.1055/a-2044-0162
DOI: 10.1055/a-2044-0162
GebFra Science
Review
Dysbiotische Co-Faktoren des Zervixkarzinoms. Der Einfluss des Mikrobioms auf die Entstehung zervikaler intraepithelialer Neoplasien (CIN)
Article in several languages: English | deutsch
Zusammenfassung
Die Infektion mit humanen Papillomaviren (HPV) ist für die Entstehung des Zervixkarzinoms eine notwendige, aber nicht hinreichende Bedingung. Die dysbiotische Verschiebung des zervikovaginalen Mikrobioms stellt offensichtlich einen wesentlichen Co-Faktor in der Karzinogenese dar. Neue Analysemethoden, wie das Next-Generation-Sequencing (NGS), erlauben die Bestimmung der Gesamtheit der vaginalen Mikroorganismen und damit die Ableitung individueller Therapieoptionen. Der Zusammenhang von bakterieller Vaginose und Karzinogenese sowie mögliche Indikationen für den Einsatz der Mikrobiom-Analyse werden diskutiert.
Publication History
Received: 09 December 2022
Accepted after revision: 20 February 2023
Article published online:
04 May 2023
© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).
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