Virtual Collection honoring Prof. Guoqiang Lin’s Contributions to Organic Chemistry
Abstract
Phosphonates and derivatives with an α-chiral center are of great importance and they
are widely distributed in many natural products, pharmaceuticals, and agrochemicals
with various bioactive features. Great effort has been made toward the development
of efficient methods for their synthesis. In this short review, recent advances in
the asymmetric catalytic synthesis of phosphonates with an α-chiral center are summarized,
including asymmetric hydrogenation of α,β-unsaturated phosphonates, asymmetric addition
of phosphonates to unsaturated electrophiles, and asymmetric addition of nucleophiles
to α,β-unsaturated phosphonates. In addition, continuous development of enantioselective
catalytic synthetic methods and the application of phosphonates and derivatives with
α-chiral center are future prospects.
1 Introduction
2 Asymmetric Hydrogenation of α,β-Unsaturated Phosphonates
3 Asymmetric Addition of Phosphonates to Unsaturated Electrophiles
4 Asymmetric Addition of Nucleophiles to α,β-Unsaturated Phosphonates
5 Conclusion
Key words
chiral phosphonates - asymmetric catalysis - asymmetric hydrogenation - asymmetric
addition - enantioselectivity
