CC BY-NC-ND 4.0 · Geburtshilfe Frauenheilkd 2023; 83(06): 686-693
DOI: 10.1055/a-2073-9534
GebFra Science

Breast Implant-Associated Tumors

Article in several languages: English | deutsch
1   Department of Plastic- and Aesthetic Surgery, Helios Klinik Emil von Behring, Berlin, Germany
Thomas Kremer
2   Klinik für Plastische und Handchirurgie mit Schwerbrandverletztenzentrum, Klinikum St. Georg, Dresden, Germany
Lukas Prantl
3   Abteilung für Plastische-, Hand- und Rekonstruktive Chirurgie, Universität Regensburg, Regensburg, Germany (Ringgold ID: RIN9147)
Alba Fricke
1   Department of Plastic- and Aesthetic Surgery, Helios Klinik Emil von Behring, Berlin, Germany
4   Department of Plastic and Hand Surgery, University of Freiburg Medical Centre, Medical Faculty of the University of Freiburg, Freiburg, Germany
› Author Affiliations


In addition to anaplastic large T-cell lymphomas (BIA-ALCL), other implant-related tumors have been described for some years. Squamous cell carcinoma (SSC) and B-cell lymphomas occurred in very rare cases. The unexplained pathogenesis as well as the unclear individual risk profile is an ongoing source of uncertainty for patients and physicians. The pathogenesis of the tumors is still largely not understood. While BIA-ALCL occurs more frequently with textured breast implants, other tumors were also observed with smooth implants and at other implant sites. Multiple potential mechanisms are discussed. It is suspected that the etiology of a chronic inflammatory response and subsequently immunostimulation is multifactorial and appears to play a key role in the malignant transformation. Since there are currently no sufficiently valid data for a specific risk assessment, this must be done with caution. This article presents the incidence, pathogenesis, as well as the level of evidence according to the current state of knowledge, and evaluates and discusses the current literature.

Publication History

Received: 06 February 2023

Accepted after revision: 13 April 2023

Article published online:
06 June 2023

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