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CC BY-NC-ND 4.0 · Geburtshilfe Frauenheilkd 2023; 83(06): 664-672
DOI: 10.1055/a-2074-0125
DOI: 10.1055/a-2074-0125
GebFra Science
Review
Update Mammakarzinom 2023 Teil 2 – Brustkrebs in fortgeschrittenen Krankheitsstadien
Article in several languages: English | deutsch
Zusammenfassung
Eine Reihe von neuen Therapien hat in den letzten Jahren die Fortschritte in der Behandlung von Patientinnen mit fortgeschrittenem Mammakarzinom bestimmt. Diese Substanzen sind hauptsächlich die CDK4/6-Inhibitoren und weitere Substanzen, welche die endokrine Resistenz überwinden können, die oralen selektiven Östrogenrezeptor-Degradierer, die Antikörper-Medikament Konjugate (ADCs) und die PARP-Inhibitoren. In dieser Übersichtsarbeit werden die neuesten Studienergebnisse zusammengefasst und bewertet, die in den letzten Monaten veröffentlicht worden sind. Dies beinhaltet die Gesamtüberlebensdaten der Destiny-Breast03-Studie, die erste Analyse der CAPItello-291-Studie, den Vergleich einer CDK4/6-Inhibitor-Therapie mit Chemotherapie in der ersten Therapielinie (RIGHT Choice-Studie), die erste Analyse der Destiny-Breast02-Studie im Therapie-Setting nach T-DM1-Therapie und die erste Analyse der Serena-2-Studie.
Die meisten dieser Studien haben das Potenzial, die Therapielandschaft für Patientinnen mit fortgeschrittenem Mammakarzinom deutlich zu verändern, und zeigen, dass die Entwicklung neuer Therapien mit einer nach wie vor hohen Geschwindigkeit immer neue Ergebnisse produziert.
Schlüsselwörter
Brustkrebs - metastatisch - endokrine Therapie - Antikörper-Medikament-Konjugat - ChemotherapiePublication History
Received: 13 April 2023
Accepted: 14 April 2023
Article published online:
06 June 2023
© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).
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