Abstract
Chiral ferrocene derivatives possessing a planar stereogenic unit are important as
chiral catalysts and materials. The principle method to obtain 1,2-disubstituted planarly
chiral ferrocenes is base-mediated ortho-metalation performed on a chiral ferrocene derivative, typically using organolithium
bases. A multitude of chiral ligands and other useful compounds have been synthesized
by using this methodology. Newer methodologies employing transition-metal-catalyzed
C–H bond activation strategies complement ortho-metalation methods and affords access to different types of planar chiral ferrocene
derivatives.
1 Introduction
2 Base-Mediated ortho-Deprotonations
3 Diastereoselective C–H Activations
4 Examples of Enantioselective C–H Activations
5 Conclusions
Key words
asymmetric synthesis - ferrocene - planar chirality -
ortho-metalation - C–H activation
