CC BY-NC-ND 4.0 · Thorac Cardiovasc Surg
DOI: 10.1055/a-2107-0481
Original Cardiovascular

Follow-Up and Outcome after Coronary Bypass Surgery Preceded by Coronary Stent Implantation

Marwan Hamiko*
1   Department of Cardiac Surgery, Universitätsklinikum Bonn, Bonn, Nordrhein-Westfalen, Germany
Nicole Konrad*
1   Department of Cardiac Surgery, Universitätsklinikum Bonn, Bonn, Nordrhein-Westfalen, Germany
Doreen Lagemann
1   Department of Cardiac Surgery, Universitätsklinikum Bonn, Bonn, Nordrhein-Westfalen, Germany
Christopher Gestrich
1   Department of Cardiac Surgery, Universitätsklinikum Bonn, Bonn, Nordrhein-Westfalen, Germany
Franz Masseli
2   Department of Cardiovascular Surgery, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Mainz, Rheinland-Pfalz, Germany
Mehmet Oezkur
2   Department of Cardiovascular Surgery, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Mainz, Rheinland-Pfalz, Germany
Markus Velten
3   Department of Anesthesiology and Intensive Care Medicine, Universitätsklinikum Bonn, Bonn, Nordrhein-Westfalen, Germany
Hendrik Treede
2   Department of Cardiovascular Surgery, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Mainz, Rheinland-Pfalz, Germany
2   Department of Cardiovascular Surgery, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Mainz, Rheinland-Pfalz, Germany
› Author Affiliations


Background Guidelines on myocardial revascularization define recommendations for percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG) surgery. Only little information exists on long-term follow-up and quality of life (QoL) after CABG preceded by PCI. The aim of our study was to evaluate the impact of prior PCI on outcome and QoL in patients with stable coronary artery disease who underwent CABG.

Methods In our retrospective study, CABG patients were divided in: CABG preceded by PCI: PCI-first (PCF), and CABG-only (CO) groups. The PCF group was further divided in guideline-conform (GCO) and guideline nonconform (GNC) subgroups, according to the SYNTAX score (2014 European Society of Cardiology [ESC]/European Association for Cardio-Thoracic Surgery [EACTS] guidelines). Thirty days mortality, major adverse cardiac events, and QoL using the European Quality-of-Life–5 Dimensions were evaluated.

Results A total of 997 patients were analyzed, of which 784 underwent CABG without (CO), and 213 individuals with prior PCI (PCF). The latter group consisted of 67 patients being treated in accordance (GCO), and 24 in discordance (GNC) to the 2014 ESC/EACTS guidelines. Reinfarction (PCF: 3.8% vs. CO: 1.0%; p = 0.024), re-angiography (PCF: 17.6% vs. CO: 9.0%; p = 0.004), and re-PCI (PCF: 10.4% vs. CO: 3.0%; p < 0.001) were observed more frequently in PCF patients. Also, patients reported better health status in the CO compared to PCF group (CO: 72.48 ± 19.31 vs. PCF: 68.20 ± 17.86; p = 0.01). Patients from the guideline nonconform subgroup reported poorer health status compared to the guideline-conform group (GNC: 64.23 ± 14.56 vs. GCO: 73.42 ± 17.66; p = 0.041) and were more likely to require re-PCI (GNC: 18.8% vs. GCO: 2.4%; p = 0.03). Also, GNC patients were more likely to have left main stenosis (GCO: 19.7% vs. GNC: 37.5%; p < 0.001) and showed higher preinterventional SYNTAX score (GCO: 18.63 ± 9.81 vs. GNC: 26.67 ± 5.07; p < 0.001).

Conclusion PCI preceding CABG is associated with poorer outcomes such as reinfarction, re-angiography, and re-PCI, but also worse health status and higher rehospitalization. Nevertheless, results were better when PCI was guideline-conformant. This data should impact the Heart Team decision.

Authors' Contribution

Conceptualization: G.D.D., M.H., C.G. Methodology: G.D.D., M.H., N.K., F.M., C.G. Software: M.H., N.K., D.L., C.G., F.M. Validation: N.K., M.H., F.M., C.G. Formal analysis: G.D.D., M.H., N.K. Investigation: G.D.D., M.H., N.K. Resources: G.D.D., N.K., D.L. Data curation: M.H., N.K., D.L., G.D.D. Writing – original draft preparation: M.H., N.K., G.D.D. Writing – review and editing: G.D.D., C.G., M.O., M.V., H.T. visualization: G.D.D., M.H., F.M., M.O., M.V., H.T. Supervision: G.D.D., M.H.. Project administration: G.D.D., M.H.

* These authors contributed equally to this article.

Supplementary Material

Publication History

Received: 14 February 2023

Accepted: 15 May 2023

Accepted Manuscript online:
07 June 2023

Article published online:
31 July 2023

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