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CC BY-NC-ND 4.0 · Thromb Haemost 2023; 123(11): 1100-1104
DOI: 10.1055/a-2149-4431
Letter to the Editor

Short-Term Western Diet Causes Rapid and Lasting Alterations of Bone Marrow Physiology

Mariaelvy Bianchini
1   Helmholtz Zentrum München, Institute of Radiation Medicine, Neuherberg, Germany
2   Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität in Munich (LMU Munich), Munich, Germany
,
Zoe Möller-Ramon
2   Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität in Munich (LMU Munich), Munich, Germany
,
Christian Weber
2   Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität in Munich (LMU Munich), Munich, Germany
3   German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany
4   Cardiovascular Research Institute Maastricht (CARIM), University of Maastricht, Maastricht, The Netherlands
,
Remco T. A. Megens‡   *
2   Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität in Munich (LMU Munich), Munich, Germany
3   German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany
4   Cardiovascular Research Institute Maastricht (CARIM), University of Maastricht, Maastricht, The Netherlands
,
Johan Duchêne‡   *
2   Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität in Munich (LMU Munich), Munich, Germany
3   German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany
› Author Affiliations
Funding This work was supported by the Deutsche Forschungsgemeinschaft grants CRC1123/Z1 (to R.T.A.M.), CRC1123/A10 (to J.D. and C.W.), INST409/97-1FUGG and INST409/150-1FUGG (to C.W. and R.T.A.M.).
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Authors' Contribution

M.B. designed and performed experiments, analyzed, and interpreted data; Z.M.-R. performed experiments, analyzed, and interpreted data; C.W. provided funding and intellectual input; R.T.A.M and J.D. provided funding, designed the research, interpreted data, and wrote the manuscript.


* These authors contributed equally to this study.


Supplementary Material



Publication History

Received: 23 December 2022

Accepted: 14 July 2023

Accepted Manuscript online:
07 August 2023

Article published online:
21 September 2023

© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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  • References

  • 1 Libby P, Buring JE, Badimon L. et al. Atherosclerosis. Nat Rev Dis Primers 2019; 5 (01) 56
    Search in Google Scholar
  • 2 Rohde D, Vandoorne K, Lee IH. et al. Bone marrow endothelial dysfunction promotes myeloid cell expansion in cardiovascular disease. Nat Cardiovasc Res 2022; 1 (01) 28-44
    Search in Google Scholar
  • 3 Morrison SJ, Scadden DT. The bone marrow niche for haematopoietic stem cells. Nature 2014; 505 (7483) 327-334
    Search in Google Scholar
  • 4 Pinho S, Frenette PS. Haematopoietic stem cell activity and interactions with the niche. Nat Rev Mol Cell Biol 2019; 20 (05) 303-320
    Search in Google Scholar
  • 5 Baccin C, Al-Sabah J, Velten L. et al. Combined single-cell and spatial transcriptomics reveal the molecular, cellular and spatial bone marrow niche organization. Nat Cell Biol 2020; 22 (01) 38-48
    Search in Google Scholar
  • 6 Gomariz A, Helbling PM, Isringhausen S. et al. Quantitative spatial analysis of haematopoiesis-regulating stromal cells in the bone marrow microenvironment by 3D microscopy. Nat Commun 2018; 9 (01) 2532
    Search in Google Scholar
  • 7 Kiel MJ, Yilmaz OH, Iwashita T, Yilmaz OH, Terhorst C, Morrison SJ. SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell 2005; 121 (07) 1109-1121
    Search in Google Scholar
  • 8 Duchene J, Novitzky-Basso I, Thiriot A. et al. Atypical chemokine receptor 1 on nucleated erythroid cells regulates hematopoiesis. Nat Immunol 2017; 18 (07) 753-761
    Search in Google Scholar
  • 9 Pietras EM, Reynaud D, Kang YA. et al. Functionally distinct subsets of lineage-biased multipotent progenitors control blood production in normal and regenerative conditions. Cell Stem Cell 2015; 17 (01) 35-46
    Search in Google Scholar
  • 10 Pelus LM, Fukuda S. Peripheral blood stem cell mobilization: the CXCR2 ligand GRObeta rapidly mobilizes hematopoietic stem cells with enhanced engraftment properties. Exp Hematol 2006; 34 (08) 1010-1020
    Search in Google Scholar
  • 11 Serbina NV, Pamer EG. Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2. Nat Immunol 2006; 7 (03) 311-317
    Search in Google Scholar
  • 12 Zink F, Stacey SN, Norddahl GL. et al. Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly. Blood 2017; 130 (06) 742-752
    Search in Google Scholar
  • 13 Jaiswal S, Natarajan P, Silver AJ. et al. Clonal hematopoiesis and risk of atherosclerotic cardiovascular disease. N Engl J Med 2017; 377 (02) 111-121
    Search in Google Scholar
  • 14 Heyde A, Rohde D, McAlpine CS. et al. Increased stem cell proliferation in atherosclerosis accelerates clonal hematopoiesis. Cell 2021; 184 (05) 1348.e22-1361.e22
    Search in Google Scholar
  • 15 Young AL, Challen GA, Birmann BM, Druley TE. Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults. Nat Commun 2016; 7: 12484
    Search in Google Scholar
  • 16 Itkin T, Gur-Cohen S, Spencer JA. et al. Distinct bone marrow blood vessels differentially regulate haematopoiesis. Nature 2016; 532 (7599) 323-328
    Search in Google Scholar
  • 17 Kusumbe AP, Ramasamy SK, Itkin T. et al. Age-dependent modulation of vascular niches for haematopoietic stem cells. Nature 2016; 532 (7599) 380-384
    Search in Google Scholar
  • 18 Kunisaki Y, Bruns I, Scheiermann C. et al. Arteriolar niches maintain haematopoietic stem cell quiescence. Nature 2013; 502 (7473) 637-643
    Search in Google Scholar
  • 19 Xu C, Gao X, Wei Q. et al. Stem cell factor is selectively secreted by arterial endothelial cells in bone marrow. Nat Commun 2018; 9 (01) 2449
    Search in Google Scholar
  • 20 Acar M, Kocherlakota KS, Murphy MM. et al. Deep imaging of bone marrow shows non-dividing stem cells are mainly perisinusoidal. Nature 2015; 526 (7571) 126-130
    Search in Google Scholar
  • 21 Chen JY, Miyanishi M, Wang SK. et al. Hoxb5 marks long-term haematopoietic stem cells and reveals a homogenous perivascular niche. Nature 2016; 530 (7589) 223-227
    Search in Google Scholar
  • 22 Yousif LF, Di Russo J, Sorokin L. Laminin isoforms in endothelial and perivascular basement membranes. Cell Adhes Migr 2013; 7 (01) 101-110
    Search in Google Scholar
  • 23 Gu YC, Kortesmaa J, Tryggvason K. et al. Laminin isoform-specific promotion of adhesion and migration of human bone marrow progenitor cells. Blood 2003; 101 (03) 877-885
    Search in Google Scholar
  • 24 Susek KH, Korpos E, Huppert J. et al. Bone marrow laminins influence hematopoietic stem and progenitor cell cycling and homing to the bone marrow. Matrix Biol 2018; 67: 47-62
    Search in Google Scholar
  • 25 Mouw JK, Ou G, Weaver VM. Extracellular matrix assembly: a multiscale deconstruction. Nat Rev Mol Cell Biol 2014; 15 (12) 771-785
    Search in Google Scholar
  • 26 Christ A, Günther P, Lauterbach MAR. et al. Western diet triggers NLRP3-dependent innate immune reprogramming. Cell 2018; 172 (1–2): 162-175.e14
    Search in Google Scholar