Exp Clin Endocrinol Diabetes 2023; 131(12): 646-655
DOI: 10.1055/a-2188-1745

Dietary and Nutritional Supplementation for Painful Diabetic Neuropathy: A Narrative Review

1   Medical School, National and Kapodistrian University of Athens, Athens,Greece
2   Diabetes Centre-Diabetic Foot Clinic, Second Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece
› Author Affiliations


Painful diabetic neuropathy (PDN) is a serious and very common complication of diabetes mellitus (DM). It negatively affects the quality of life, increases morbidity and poses a financial burden on the health care system. Currently, treatment of PDN focuses on glycaemic control, while pathogenesis-oriented therapy has not yielded satisfactory results. The need to improve therapy remains. There is accumulating evidence on the potential benefit of nutritional interventions. This narrative review aims to examine the potential benefit of dietary and nutritional supplementation for PDN management. According to the preliminary research, supplementation with vitamin E, B-complex, omega-3 fatty acids, CoQ10 or N-acetylcysteine seems to be associated with promising results in improving PDN symptoms.

Publication History

Received: 06 June 2023
Received: 30 September 2023

Accepted: 06 October 2023

Accepted Manuscript online:
09 October 2023

Article published online:
06 December 2023

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