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Hamostaseologie 2024; 44(01): 013-020
DOI: 10.1055/a-2219-6410
Review Article

Clonal Hematopoiesis and Cardiovascular Risk: Atherosclerosis, Thrombosis, and beyond

Benedetta Izzi
1   Centro Nacional de Investigaciones Cardiovasculares (CNIC). Madrid, Spain
,
José J. Fuster
1   Centro Nacional de Investigaciones Cardiovasculares (CNIC). Madrid, Spain
2   CIBER en Enfermedades Cardiovasculares (CIBER-CV), Madrid, Spain
› Author Affiliations Funding Research work in our laboratory related to this topic is supported by grant PLEC2021-008194, funded by MCIN/AEI/10.13039/501100011033 and by the “European Union NextGenerationEU/PRTR”; by grant PID2021-126580OB-I00, funded by MCIN/AEI/10.13039/501100011033 and by “ERDF A way of making Europe”; and by the “la Caixa” Foundation (ID 100010434) under agreement LCF/PR/HR22/00732. BI is supported by the program Atracción de Talento of the Comunidad de Madrid (GN: 2022-T1/BMD-23767). The CNIC is supported by the MICIN, the Instituto de Salud Carlos III, the Pro-CNIC Foundation, and is a Severo Ochoa Center of Excellence (grant number CEX2020-001041-S).
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Abstract

Acquired mutations that lead to clonal hematopoiesis have emerged as a new and potent risk factor for atherosclerotic cardiovascular disease and other cardiovascular conditions. Human sequencing studies and experiments in mouse models provide compelling evidence supporting that this condition, particularly when driven by specific mutated genes, contributes to the development of atherosclerosis by exacerbating inflammatory responses. The insights gained from these studies are paving the way for the development of new personalized preventive care strategies against cardiovascular disease. Furthermore, available evidence also suggests a potential relevance of these mutation in the context of thrombosis, an area requiring thorough investigation. In this review, we provide an overview of our current understanding of this emerging cardiovascular risk factor, focusing on its relationship to atherosclerosis and thrombosis.

Keywords

CHIP - atherosclerosis - thrombosis - inflammation - TET2


Publication History

Received: 31 October 2023

Accepted: 11 November 2023

Article published online:
28 February 2024

© 2024. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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