Liver transplantation meets gastrointestinal cancer

Sven H. Loosen; Catherine Leyh; Ulf Peter Neumann; Hans Bock; Christian Weigel; Tom Luedde; Christoph Roderburg

doi:10.1055/a-2226-0123

Zeitschrift für Gastroenterologie, Table of Contents

Z Gastroenterol 2024; 62(01): 62-72
DOI: 10.1055/a-2226-0123

Übersicht

Liver transplantation meets gastrointestinal cancer

Lebertransplantation bei gastrointestinalen Tumoren

Authors

Sven H. Loosen

¹Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany (Ringgold ID: RIN39064)

²Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Düsseldorf, Germany
Catherine Leyh

¹Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany (Ringgold ID: RIN39064)

²Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Düsseldorf, Germany
Ulf Peter Neumann

³Department of General, Visceral and Transplantation Surgery, University Hospital RWTH Aachen, Aachen, Germany

⁴Department of Surgery and Transplantation, University Hospital Essen, Essen, Germany
Hans Bock

¹Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany (Ringgold ID: RIN39064)

²Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Düsseldorf, Germany
Christian Weigel

²Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Düsseldorf, Germany

¹Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany (Ringgold ID: RIN39064)
Tom Luedde

¹Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany (Ringgold ID: RIN39064)

²Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Düsseldorf, Germany
Christoph Roderburg

¹Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany (Ringgold ID: RIN39064)

²Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Düsseldorf, Germany

Abstract

Liver transplantation (LT) has emerged as a standard of care for patients with end-stage liver disease, providing a life-saving intervention for patients with severely compromised liver function in both the acute and chronic setting. While LT has also become a routine procedure for early-stage hepatocellular carcinoma (HCC), offering a potential cure by treating both the tumor and the underlying liver disease, its relevance in the context of other malignancies such as cholangiocellular carcinoma (CCA), combined hepatocellular-cholangiocarcinoma (cHCC-CCA) or liver metastases is still the subject of intense debate and no definite recommendations have yet been established. This review summarizes the current therapeutic standards in the context of LT for gastrointestinal malignancies and provides a reflection and outlook on current scientific and clinical developments.

Zusammenfassung

Die Lebertransplantation (LT) hat sich als Standardbehandlung für Patienten mit Lebererkrankungen im Endstadium etabliert und stellt sowohl im akuten als auch im chronischen Stadium einen lebensrettenden Eingriff für Patienten mit stark eingeschränkter Leberfunktion dar. Während die Lebertransplantation auch für das hepatozelluläre Karzinom (HCC) im Frühstadium zu einem Routineverfahren geworden ist und eine potenzielle Heilung bietet, indem sowohl der Tumor als auch die zugrunde liegende Lebererkrankung behandelt werden, wird ihre Relevanz im Zusammenhang mit anderen bösartigen Erkrankungen wie dem cholangiozellulären Karzinom (CCA), dem kombinierten hepatozellulären/cholangiozellulären Karzinom (cHCC-CCA) oder Lebermetastasen noch immer intensiv diskutiert, und es gibt noch keine definitiven Empfehlungen. Diese Übersicht fasst die aktuellen Therapiestandards im Rahmen der LT bei gastrointestinalen Malignomen zusammen und gibt einen Überblick über und Ausblick auf die aktuellen wissenschaftlichen und klinischen Entwicklungen.

Keywords

HCC - CCA - cHCC/CCA - MELD - Eurotransplant - liver transplantation

Schlüsselwörter

HCC - CCC - cHCC/CCC - MELD - Eurotransplant - Lebertransplantation

Full Text

References

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