Subscribe to RSS
DOI: 10.1055/a-2233-4301
Psychedelika in der Psychiatrie
Einführung und Stand klinischer Studien
ZUSAMMENFASSUNG
Psychedelika stoßen in der Psychiatrie auf ein erneut zunehmendes fachliches und wissenschaftliches Interesse. Nach einer intensiveren Phase des Einsatzes im psychotherapeutischen Kontext Mitte des letzten Jahrhunderts kam die Forschung in dem Bereich nach gesetzlichen Verboten weitestgehend zum Erliegen. Erst seit wenigen Jahren wird das klinische Potenzial wieder mit modernen wissenschaftlichen Methoden erforscht. Die Eigenschaft der Psychedelika, qualitativ veränderte Bewusstseinszustände mit auch psychodynamischen Erfahrungen und Erkenntnissen hervorzurufen, legt die Möglichkeit nahe, sie zur Unterstützung von psychotherapeutischen Prozessen zu nutzen. Bisherige Indikationsgebiete von klinischen Studien betreffen vor allem den Einsatz bei therapieresistenten Depressionen, aber auch bei posttraumatischen Belastungsstörungen und Alkoholabhängigkeit. Allerdings muss festgehalten werden, dass eine spezifische Psychedelika-Psychotherapie im engeren Sinnen noch nicht erforscht wird. Neben dem Ausbau der Evidenzlage ist in diesem Feld noch einiges vor einem eventuellen breiteren klinischen Einsatz zu erarbeiten.
Publication History
Article published online:
14 May 2024
© 2024. Thieme. All rights reserved.
Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany
-
Literatur
- 1 Akers B, Ruiz JF, Piper A. et al A Prehistoric Mural in Spain Depicting Neurotropic Psilocybe Mushrooms. Economic Botany 2011; 65 (02) 121-128
- 2 Beringer K.. Der Mescalinrausch. Seine Geschichte und Erscheinungsweise. Berlin: Julius Springer; 1927
- 3 Herwig U, Mertens L, Perez Rosal S. et al Psychedelika in der Psychiatrie – Entwicklungen und die Stellung in Deutschland. Fortschr Neurol Psychiatr 2023; 91: 311-318
- 4 Passie T, Guss J, Krähenmann R. Lower-dose psycholytic therapy – A neglected approach. Front Psychiatry 2022; 13: 1020505
- 5 Mascher E.. Psycholytic therapy: statistics and indications. In: Brill, H. et al. eds. Neuro-Psychopharmacology. Amsterdam: Excerpta Medica Foundation 1967: 441-414
- 6 Holze F, Singh N, Liechti ME. et al Serotonergic Psychedelics – a Comparative review Comparing the Efficacy, Safety, Pharmacokinetics and Binding Profile of Serotonergic Psychedelics. Biol Psychiatry Cogn Neurosci Neuroimaging 2024; 30: S2451-9022 (24)00020-X
- 7 Roth BL, Gumpper RH. Psychedelics as Transformative Therapeutics. Am J Psychiatry 2023; 180 (05) 340-347
- 8 Vollenweider FX, Kometer M. The neurobiology of psychedelic drugs: implications for the treatment of mood disorders. Nat Rev Neurosci 2010; 11 (09) 642-651
- 9 Griffiths RR, Richards WA, McCann U. et al Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance. Psychopharmacol 2006; 187 (03) 268-283
- 10 Leuner H.. Halluzinogene. Psychische Grenzzustände in Therapie und Forschung. Bern: Verlag Hans Huber; 1981
- 11 Dittrich A. The standardized psychometric assessment of altered states of consciousness (ASCs) in humans. Pharmacopsychiatry. 1998 Suppl 2 80-84
- 12 Holze F, Ley L, Müller F. et al Direct comparison of the acute effects of lysergic acid diethylamide and psilocybin in a double-blind placebo-controlled study in healthy subjects. Neuropsychopharmacology 2022
- 13 Nutt DJ, King LA, Phillips LD. et al Drug harms in the UK: a multicriteria decision analysis. Lancet 2010; 376 9752 1558-1565
- 14 Griffiths RR, Johnson MW, Richards WA. et al Psilocybin occasioned mystical-type experiences: immediate and persisting dose-related effects. Psychopharmacology 2011; 218 (04) 649-665
- 15 Hendricks PS, Thorne CB, Clark CB. et al Classic psychedelic use is associated with reduced psychological distress and suicidality in the United States adult population. J Psychopharmacol 2015; 29 (03) 280-288
- 16 Grob CS, Danforth AL, Chopra GS. et al Pilot study of psilocybin treatment for anxiety in patients with advanced-stage cancer. Arch Gen Psychiatry 2011; 68 (01) 71-78
- 17 Gasser P, Holstein D, Michel Y. et al Safety and efficacy of lysergic acid diethylamide-assisted psychotherapy for anxiety associated with life-threatening diseases. J Nerv Ment Dis 2014; 202 (07) 513-520
- 18 Carhart-Harris RL, Bolstridge M, Rucker J. et al Psilocybin with psychological support for treatment-resistant depression: an open-label feasibility study. Lancet Psychiatry 2016; 03 (07) 619-627
- 19 Carhart-Harris RL, Bolstridge M, Day CMJ. et al Psilocybin with psychological support for treatment-resistant depression: six-month follow-up. Psychopharmacology (Berl). 2018; 235 (02) 399-408
- 20 Davis AK, Barrett FS, May DG. et al Effects of Psilocybin-Assisted Therapy on Major Depressive Disorder: A Randomized Clinical Trial. JAMA Psychiatry. 2021; 78 (05) 481-489
- 21 Gukasyan N, Davis AK, Barrett FS. et al Efficacy and safety of psilocybin-assisted treatment for major depressive disorder: Prospective 12-month follow-up. J Psychopharmacol 2022; 36 (02) 151-158
- 22 Carhart-Harris R, Giribaldi B, Watts R. et al Trial of Psilocybin versus Escitalopram for Depression. N Engl J Med 2021; 384 (15) 1402-1411
- 23 Weiss B, Erritzoe D, Giribaldi B. et al A critical evaluation of QIDS-SR-16 using data from a trial of psilocybin therapy versus escitalopram treatment for depression. J Psychopharmacol 2023; 37 (07) 717-732
- 24 Goodwin GM, Aaronson ST, Alvarez O. et al Single-Dose Psilocybin for a Treatment-Resistant Episode of Major Depression. N Engl J Med 2022; 387 (18) 1637-1648
- 25 Goodwin GM, Croal M, Feifel D. et al Psilocybin for treatment resistant depression in patients taking a concomitant SSRI medication. Neuropsychopharmacology 2023; 48 (10) 1492-1499
- 26 von Rotz R, Schindowski EM, Jungwirth J. et al Single-dose psilocybin-assisted therapy in major depressive disorder: A placebo-controlled, double-blind, randomised clinical trial. EClinicalMedicine 2022; 56: 101809
- 27 Raison CL, Sanacora G, Woolley J. et al Single-Dose Psilocybin Treatment for Major Depressive Disorder: A Randomized Clinical Trial. JAMA 2023; 330 (09) 843-853
- 28 Roseman L, Nutt DJ, Carhart-Harris RL. Quality of Acute Psychedelic Experience Predicts Therapeutic Efficacy of Psilocybin for Treatment-Resistant Depression. Front Pharmacol 2018; 08: 974
- 29 Bogenschutz MP, Forcehimes AA, Pommy JA. et al Psilocybin-assisted treatment for alcohol dependence: a proof-of-concept study. J Psychopharmacol 2015; 29 (03) 289-99
- 30 Bogenschutz MP, Ross S, Bhatt S. et al Percentage of Heavy Drinking Days Following Psilocybin-Assisted Psychotherapy vs Placebo in the Treatment of Adult Patients With Alcohol Use Disorder: A Randomized Clinical Trial. JAMA Psychiatry 2022; 79 (10) 953-962
- 31 Mithoefer MC, Wagner MT, Mithoefer AT. et al The safety and efficacy of { ± }3,4-methylenedioxymethamphetamine-assisted psychotherapy in subjects with chronic, treatment-resistant posttraumatic stress disorder: the first randomized controlled pilot study. J Psychopharmacol 2011; 25 (04) 439-452
- 32 Mitchell JM, Bogenschutz M, Lilienstein A. et al MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study. Nat Med 2021; 27 (06) 1025-1033
- 33 Mitchell JM, Ot’alora G M, van der Kolk B. et al MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial. Nat Med 2023; 29 (10) 2473-2480
- 34 Reckweg JT, van Leeuwen CJ, Henquet C. et al A phase ½ trial to assess safety and efficacy of a vaporized 5-methoxy-N,N-dimethyltryptamine formulation (GH001) in patients with treatment-resistant depression. Front Psychiatry 2023; 14: 1133414
- 35 Mash DC. IUPHAR – invited review – Ibogaine – A legacy within the current renaissance of psychedelic therapy. Pharmacol Res 2023; 190: 106620
- 36 Cherian KN, Keynan JN, Anker L. et al Magnesium-ibogaine therapy in veterans with traumatic brain injuries. Nat Med 2024
- 37 Holze F, Gasser P, Müller F. et al Lysergic Acid Diethylamide-Assisted Therapy in Patients With Anxiety With and Without a Life-Threatening Illness: A Randomized, Double-Blind, Placebo-Controlled Phase II Study. Biol Psychiatry 2023; 93 (03) 215-223
- 38 Gründer G, Brand M, Mertens LJ. et al Treatment with psychedelics is psychotherapy: beyond reductionism. Lancet Psychiatry. 2023 S2215-0366(23)00363–2. doi: 10.1016/S2215-0366(23)00363-2
- 39 Goodwin GM, Malievskaia E, Fonzo GA. et al Must Psilocybin Always “Assist Psychotherapy”?. Am J Psychiatry 2024; 181 (01) 20-25
- 40 Aicher HD, Schmid Y, Gasser P.. Psychedelika-assistierte Psychotherapie. Psychotherapie 2024; 69: 98-106
- 41 Ponomarenko P, Seragnoli F. Calder et al Can psychedelics enhance group psychotherapy? A discussion on the therapeutic factors. J Psychopharmacol 2023; 37 (07) 660-678
- 42 Barber GS, Aaronson ST. The Emerging Field of Psychedelic Psychotherapy. Curr Psychiatry Rep 2022; 24 (10) 583-590
- 43 Oehen P, Gasser P. Using a MDMA- and LSD-Group Therapy Model in Clinical Practice in Switzerland and Highlighting the Treatment of Trauma-Related Disorders. Front Psychiatry 2022; 13: 863552