Organocatalytic Atroposelective Reactions of Alkynes

Zhi-Xin Zhang; Tian-Qi Hu; Long-Wu Ye; Bo Zhou

doi:10.1055/a-2241-3571

Synthesis, Inhaltsverzeichnis

Synthesis 2024; 56(15): 2316-2328
DOI: 10.1055/a-2241-3571

short review

Organocatalytic Atroposelective Reactions of Alkynes

Autor*innen

Zhi-Xin Zhang

^aKey Laboratory of Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, P. R. of China
Tian-Qi Hu

^aKey Laboratory of Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, P. R. of China
Long-Wu Ye

^aKey Laboratory of Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, P. R. of China

^bState Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, P. R. of China
Bo Zhou ∗

^aKey Laboratory of Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, P. R. of China

Abstract

Alle Artikel dieser Rubrik

Abstract

The atroposelective transformation of alkynes is an efficient protocol for the assembly of axially chiral compounds. Benefitting from the rapid development of chiral organocatalysts, the organocatalytic atroposelective reactions of alkynes have been extensively studied over the past decades. An array of chiral catalysts, including chiral Brønsted acid catalysts, secondary amine catalysts, N-heterocyclic carbene (NHC) catalysts, thiourea catalysts and N-squaramide catalysts, are employed in enantioselective reactions of different alkynes. This short review summarizes the recent advances on organocatalytic atroposelective reactions of alkynes according to the type of alkyne substrate. The reaction mechanisms, modes of enantiocontrol, product diversity and applications are highlighted.

1 Introduction

2 Electron-Rich Aryl Alkynes

3 Electron-Deficient Aryl Alkynes

4 Other Types of Alkynes

5 Conclusion and Outlook

Key words

organocatalysis - enantioselectivity - alkynes - axially chiral compounds - reaction mechanism

Volltext

Referenzen

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