Anticoagulation Stewardship to Bridge the Implementation Gap in Perioperative Anticoagulation Management

Abstract

Lack of alignment of care protocols among providers in health care is a driver of increased costs and suboptimal patient outcomes. Perioperative anticoagulation management is a good example of a complex area where protocol creation is a clinical challenge that demands input from multiple experts. Questions regarding the need for anticoagulation interruptions are frequent. Yet, due to layers of complexity involving analysis of anticoagulation indication, surgical risk, and anesthesia-associated bleeding risk as well as institutional practices, there is heterogeneity in how these interruptions are approached. The recent perioperative anticoagulation guidelines from the American College of Chest Physicians summarize extensive evidence for the management of anticoagulant and antiplatelet medications in patients who undergo elective interventions. However, implementation of these guidelines by individual clinicians is highly varied and often does not follow the best available clinical evidence. Against this background, anticoagulation stewardship units, which exist to improve safety and quality monitoring for the anticoagulated patient, are of growing interest. These units provide a bridge for the implementation of value-based, high-quality guidelines for patients who need perioperative anticoagulation interruption. We use a case to pragmatically illustrate the problem and tactics for change management and implementation science that may facilitate the adoption of perioperative anticoagulation guidelines.

Keywords

perioperative - anticoagulation - implementation - six sigma - nudge - guidelines

Disclosures (past 3 years for me)

A.J.T.: Educational Grant: Janssen. Research Support: Biotap, Janssen, Bristol-Myers Squibb, Anthos, Novartis, Idorsia, Stago, Laguna Health, Doasense. Consulting: Recovery Force.

G.D.B. Grant Funding: Boston Scientific; Consulting: Pfizer, Bristol-Myers Squibb, Janssen, Bayer, AstraZeneca, Sanofi, Anthos, Abbott Vascular, Boston Scientific; DSMB: Translational Sciences (Clinical Events Adjudication Committee); Board of Directors: Anticoagulation Forum

V.C.B.: Honoraria:Bayer

J.D.: Consulting or Education Honoraria: Pfizer, Servier, Leo Pharma, Fresinius Kabi, CytSorb; Non-Employee Contributions with Royalties: Up-to-Date, Merck Manual

Publication History

Received: 13 August 2023

Accepted: 18 December 2023

Accepted Manuscript online:
01 February 2024

Article published online:
11 March 2024

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