The NFκB Signaling Pathway Is Involved in the Pathophysiological Process of Preeclampsia

Abstract

The high prevalence of preeclampsia (PE) is a major cause of maternal and fetal mortality and affects the long-term prognosis of both mother and baby. Termination of pregnancy is currently the only effective treatment for PE, so there is an urgent need for research into its pathogenesis and the development of new therapeutic approaches. The NFκB family of transcription factors has an essential role in inflammation and innate immunity. In this review, we summarize the role of NFκB in normal and preeclampsia pregnancies, the role of NFκB in existing treatment strategies, and potential NFκB treatment strategies.

Zusammenfassung

Die hohe Prävalenz von Präeklampsie (PE) ist eine wesentliche Ursache mütterlicher und fetaler Mortalität und wirkt sich auch auf die Langzeitprognose von Mutter und Kind aus. Der Schwangerschaftsabbruch stellt zurzeit die einzig effektive Therapie gegen PE dar. Damit besteht ein dringender Bedarf nach weiterer Forschung zur Pathogenese von PE sowie zur Entwicklung neuer Therapieansätze. Die NFκB-Familie der Transkriptionsfaktoren spielt eine wichtige Rolle in Entzündungsprozessen und für die angeborene Immunität. In dieser Übersichtsstudie fassen wir die Rolle von NFκB bei normalen und Präeklampsie-Schwangerschaften sowie die Bedeutung von NFκB in bereits existierenden Therapien und potenzielle NFκB-Behandlungsstrategien zusammen.

Keywords

inflammation - NFκB - preeclampsia (PE) - pregnancy - treatment

Schlüsselwörter

Entzündung - NFκB - Präeklampsie (PE) - Schwangerschaft - Therapie

Publication History

Received: 02 November 2023

Accepted after revision: 20 February 2024

Article published online:
10 April 2024

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