Restless-Legs-Syndrom

Bewegungsdrang von unterschiedlichem Schweregrad, begleitet von oder verursacht durch unangenehme, z.T. schmerzhafte Missempfindungen mit Spannung, Brennen oder Kribbeln, meist in den Beinen, seltener in den Armen, die bevorzugt in Ruhesituationen sowie am Abend und mit Verursachung von Ein- und Durchschlafstörungen in der Nacht auftreten und sich in der Regel durch Bewegung lindern lassen.

Publication History

Article published online:
05 June 2024

• Literatur

• 1 Yeh P, Walters AS, Tsuang JW. Restless legs syndrome: a comprehensive overview on its epidemiology, risk factors, and treatment. Sleep Breath 2012; 16: 987-1007 DOI: 10.1007/s11325-011-0606-x. (PMID: 22038683)
• 2 Ondo W, Jankovic J. Restless legs syndrome: clinicoetiologic correlates. Neurol 1996; 47: 1435-1441 DOI: 10.1212/wnl.47.6.1435. (PMID: 8960723)
• 3 Walters AS, LeBrocq C, Dhar A. et al. Validation of the International Restless Legs Syndrome Study Group rating scale for restless legs syndrome. Sleep Med 2003; 4: 121-132 DOI: 10.1016/s1389-9457(02)00258-7. (PMID: 14592342)
• 4 Allen RP, Picchietti DL, Garcia-Borreguero D. et al. Restless legs syndrome/Willis-Ekbom disease diagnostic criteria: updated International Restless Legs Syndrome Study Group (IRLSSG) consensus criteria--history, rationale, description, and significance. Sleep Med 2014; 15: 860-873 DOI: 10.1016/j.sleep.2014.03.025. (PMID: 25023924)
• 5 Neau JP, Marion P, Mathis S. et al. Restless legs syndrome and pregnancy: follow-up of pregnant women before and after delivery. Eur Neurol 2010; 64: 361-366
• 6 Winkelman JW, Armstrong MJ, Allen RP. et al. Practice guideline summary: Treatment of restless legs syndrome in adults: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology. Neurol 2016; 87: 2585-2593 DOI: 10.1212/WNL.0000000000004047. (PMID: 28607140)
• 7 Trenkwalder C, Benes H, Grote L. et al. Prolonged release oxycodone-naloxone for treatment of severe restless legs syndrome after failure of previous treatment: a double-blind, randomised, placebo-controlled trial with an open-label extension. Lancet Neurol 2013; 12: 1141-1150
• 8 Allen RP, Chen C, Garcia-Borreguero D. et al. Comparison of pregabalin with pramipexole for restless legs syndrome. N Engl J Med 2014; 370: 621-631
• 9 Trotti LM, Bhadriraju S, Becker LA. Iron for restless legs syndrome. Cochrane Database Syst Rev 2012; (05) CD007834 DOI: 10.1002/14651858.CD007834.pub2. (PMID: 22592724)
• 10 Garcia-Borreguero D, Williams AM. Dopaminergic augmentation of restless legs syndrome. Sleep Med Rev 2010; 14: 339-346 DOI: 10.1016/j.sleep.2011.03.004. (PMID: 21493133)
• 11 Earley CJ. The importance of oral iron therapy in restless legs syndrome. Sleep Med 2009; 10: 945-946 DOI: 10.1016/j.sleep.2008.12.003. (PMID: 19138879)
• 12 Trenkwalder C, Winkelmann J, Inoue Y. et al. Restless legs syndrome-current therapies and management of augmentation. Nat Rev Neurol 2015; 11: 434-445 DOI: 10.1038/nrneurol.2015.122. (PMID: 26215616)