Exercise Improves Respiratory Function, Body Fluid and Nitric Oxide
                    in Hemodialysis Patients

Rodrigo Vanerson Passos Neves; Hugo Luca Corrêa; Andrea Lucena Reis; Rosangela Vieira Andrade; Thais Branquinho Araújo; Rafael Lavarini Santos; Fernanda Félix Santos Oliveira; Guilherme Eduardo Barbosa Moraes Araújo; André Victor Gulyas Marra; Thaís Amaral Baracho; Taynah Oliveira Martins; Jessica Mycaelle da Silva Barbosa; Mariana Neiva Garcia; Nicole Messenberg Guimarães Miller; Lysleine Alves Deus; Thiago dos Santos Rosa

doi:10.1055/a-2348-2684

International Journal of Sports Medicine, Inhaltsverzeichnis

Int J Sports Med 2024; 45(13): 994-1004
DOI: 10.1055/a-2348-2684

Clinical Sciences

Exercise Improves Respiratory Function, Body Fluid and Nitric Oxide in Hemodialysis Patients

Rodrigo Vanerson Passos Neves

¹Graduate Programm in Physical Education, Catholic University of Brasilia, Taguatinga, Brazil

,

Hugo Luca Corrêa

²Physical Education, Catholic University of Brasilia, Taguatinga, Brazil

,

Andrea Lucena Reis

²Physical Education, Catholic University of Brasilia, Taguatinga, Brazil

,

Rosangela Vieira Andrade

³Graduate Program in Biotechnology, Catholic University of Brasilia, Taguatinga, Brazil

,

Thais Branquinho Araújo

²Physical Education, Catholic University of Brasilia, Taguatinga, Brazil

,

Rafael Lavarini Santos

⁴Graduate Program in Genomic Science and Biotechnology, Catholic University of Brasilia, Taguatinga, Brazil

,

Fernanda Félix Santos Oliveira

¹Graduate Programm in Physical Education, Catholic University of Brasilia, Taguatinga, Brazil

,

Guilherme Eduardo Barbosa Moraes Araújo

¹Graduate Programm in Physical Education, Catholic University of Brasilia, Taguatinga, Brazil

,

André Victor Gulyas Marra

¹Graduate Programm in Physical Education, Catholic University of Brasilia, Taguatinga, Brazil

,

Thaís Amaral Baracho

¹Graduate Programm in Physical Education, Catholic University of Brasilia, Taguatinga, Brazil

,

Taynah Oliveira Martins

⁵Graduate Program in Physical Education, Catholic University of Brasilia, Riacho Fundo I, Brazil

,

Jessica Mycaelle da Silva Barbosa

⁶Nutrition, Catholic University of Brasilia, Taguatinga, Brazil

,

Mariana Neiva Garcia

¹Graduate Programm in Physical Education, Catholic University of Brasilia, Taguatinga, Brazil

,

Nicole Messenberg Guimarães Miller

¹Graduate Programm in Physical Education, Catholic University of Brasilia, Taguatinga, Brazil

,

Lysleine Alves Deus

¹Graduate Programm in Physical Education, Catholic University of Brasilia, Taguatinga, Brazil

,

Thiago dos Santos Rosa

⁷Graduate Program in Physical Education and Graduate Program in Genomic Sciences and Biotechnology, Catholic University of Brasilia, Taguatinga, Brazil

› Institutsangaben

Abstract

Emerging evidence suggests that resistance training (RT) can mitigate respiratory muscle weakness in hemodialysis (HD) patients. However, the underlying mechanisms responsible for these beneficial effects remain unclear. The purpose of this study was to assess the impact of periodized RT on respiratory muscle strength and its relationship with handgrip strength (HGS), fat-free mass (FFM), nitric oxide (NO), and interdialytic weight gain (IWG) in HD patients. Thirty-three patients were randomly assigned to two groups: control (CTL; n=18) and RT (n=15). The RT group did not perform any additional exercise training specific to the respiratory tract. Maximal inspiratory (MIP) and expiratory (MEP) pressures, peak expiratory flow (PEF), HGS, FFM, NO, and IWG were measured before and after the intervention period. Participants in the RT group engaged in a 24-week RT program, three times per week. RT resulted in significant improvements in MIP, MEP, PEF, as well as enhancements in HGS, FFM, NO, and IWG (p<0.05). Notably, inverse correlations were observed between MIP (r=−0.37, p=0.03) and PEF (r=−0.4, p=0.02) with IWG. Thus, the amelioration of HGS and FFM coincided with a reduction in respiratory muscle weakness among HD patients. Decreased IWG and increased circulating NO are plausible mechanisms contributing to these improvements.

Keywords

exercise - end-stage renal disease - respiratory performance - lung - endothelial dysfunction - edema

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Referenzen

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