Aktuelle Urol
DOI: 10.1055/a-2354-3573
Original Article

Role of the Triglyceride-Glucose Index as a Predictor of Therapeutic Response to Tadalafil in Patients With Erectile Dysfunction

Triglycerid-Glukose-Index als Prädiktor des Therapieansprechens auf Tadalafil bei Patienten mit erektiler Dysfunktion
Ufuk Caglar
1   Urology, Haseki Training and Research Hospital, Istanbul, Turkey (Ringgold ID: RIN147013)
,
Oguzhan Yildiz
1   Urology, Haseki Training and Research Hospital, Istanbul, Turkey (Ringgold ID: RIN147013)
,
Resit Yusuf
1   Urology, Haseki Training and Research Hospital, Istanbul, Turkey (Ringgold ID: RIN147013)
,
2   Urology, Haseki Training and Research Hospital, Turkey (Ringgold ID: RIN147013)
,
Abdullah Esmeray
1   Urology, Haseki Training and Research Hospital, Istanbul, Turkey (Ringgold ID: RIN147013)
,
Omer Sarilar
1   Urology, Haseki Training and Research Hospital, Istanbul, Turkey (Ringgold ID: RIN147013)
,
Faruk Ozgor
1   Urology, Haseki Training and Research Hospital, Istanbul, Turkey (Ringgold ID: RIN147013)
› Author Affiliations

Abstract

Introduction: The triglyceride-glucose (TyG) index is an easily calculable indicator of endothelial dysfunction. We aimed to evaluate the effect of the TyG index on treatment response in patients using tadalafil for the treatment of erectile dysfunction (ED).

Methods: The data of patients who used tadalafil for ED in our urology clinic between January 2018 and January 2023 were reviewed. The patients completed the 5-item International Index of Erectile Function (IIEF-5) questionnaire before treatment and in the 3rd month of treatment. Response to tadalafil treatment was accepted as an increase in IIEF category. Patients were divided into 2 groups according to treatment response. Factors affecting response to treatment were evaluated with a multivariate analysis.

Results: Of the 134 patients included in the study, 99 (73.3%) responded to tadalafil treatment. Mean age and body mass index (BMI) of the patient group responding to treatment were significantly lower than in the untreated group. The rates of diabetes mellitus (DM) and metabolic syndrome (MetS) were significantly lower in the group responding to treatment. Fasting glucose, triglyceride and total cholesterol values were significantly lower in the group responding to treatment than in the treatment-resistant group. The TyG index was 130.0 (102.0–180.0) in the group responding to treatment and 245.0 (182.0–320.0) in the treatment-resistant group (p=0.001). In the multivariate analysis, age, BMI, DM, MetS, and TyG index were affecting treatment response.

Conclusion: A high TyG index negatively affects the response to treatment in patients using tadalafil for ED. In addition, age, BMI, presence of DM and MetS are other factors affecting the response to treatment.

Zusammenfassung

Einleitung: Der Triglycerid-Glukose (TyG) -Index ist ein leicht zu berechnender Indikator für endotheliale Dysfunktion. Unser Ziel war es, den Einfluss des TyG-Index auf die Behandlungsantwort bei Patienten zu bewerten, die Tadalafil zur Behandlung von erektiler Dysfunktion (ED) verwenden.

Methoden: Die Daten von Patienten, die zwischen Januar 2018 und Januar 2023 Tadalafil zur Behandlung von ED in unserer Urologieklinik verwendet haben, wurden überprüft. Die Patienten haben den 5-Item International Index of Erectile Function (IIEF-5) Fragebogen vor der Behandlung und im 3. Monat der Behandlung ausgefüllt. Eine Antwort auf die Tadalafil-Behandlung wurde als eine Erhöhung der IIEF-Kategorie akzeptiert. Die Patienten wurden in 2 Gruppen eingeteilt, je nach Behandlungsantwort. Faktoren, die die Behandlungsantwort beeinflussen, wurden mit multivariater Analyse bewertet.

Ergebnisse: Von den 134 in die Studie eingeschlossenen Patienten reagierten 99 (73,3 %) auf die Tadalafil-Behandlung. Das durchschnittliche Alter und der Body-Mass-Index (BMI) der Patientengruppe, die auf die Behandlung ansprach, waren signifikant niedriger als in der unbehandelten Gruppe. Die Raten von Diabetes Mellitus (DM) und metabolischem Syndrom (MetS) waren in der behandlungsansprechenden Gruppe signifikant niedriger. Nüchternblutzucker-, Triglycerid- und Gesamtcholesterinwerte waren in der behandlungsansprechenden Gruppe signifikant niedriger als in der behandlungsresistenten Gruppe. Der TyG-Index betrug 130,0 (102,0–180,0) in der behandlungsansprechenden Gruppe und 245,0 (182,0–320,0) in der behandlungsresistenten Gruppe (p=0,001). In der multivariaten Analyse beeinflussten Alter, BMI, DM, MetS und TyG-Index die Behandlungsantwort.

Schlussfolgerung: Ein hoher TyG-Index wirkt sich negativ auf die Behandlungsantwort bei Patienten aus, die Tadalafil zur Behandlung von ED verwenden. Darüber hinaus sind Alter, BMI, das Vorhandensein von DM und MetS weitere Faktoren, die die Behandlungsantwort beeinflussen.



Publication History

Received: 20 March 2024

Accepted: 19 June 2024

Article published online:
24 July 2024

© 2024. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
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