Applications of Sulfonyl Fluorides in Organic Transformations

Sichang Wang; Chengxiang Zhou; Yunzi Han; Miao Li; Congyu Ke; Shenlin Huang

doi:10.1055/a-2446-8203

Synthesis, Inhaltsverzeichnis

Synthesis 2025; 57(11): 1817-1832
DOI: 10.1055/a-2446-8203

short review

SuFEx Chemistry

Applications of Sulfonyl Fluorides in Organic Transformations

Autor*innen

Sichang Wang

^aCollege of Chemistry and Chemical Engineering, Xi’an Shiyou University, Xi’an 710065, P. R. China
Chengxiang Zhou

^aCollege of Chemistry and Chemical Engineering, Xi’an Shiyou University, Xi’an 710065, P. R. China
Yunzi Han

^aCollege of Chemistry and Chemical Engineering, Xi’an Shiyou University, Xi’an 710065, P. R. China
Miao Li

^aCollege of Chemistry and Chemical Engineering, Xi’an Shiyou University, Xi’an 710065, P. R. China
Congyu Ke∗

^aCollege of Chemistry and Chemical Engineering, Xi’an Shiyou University, Xi’an 710065, P. R. China
Shenlin Huang ∗

^bJiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, International Innovation Center for Forest Chemicals and Materials, Nanjing Forestry University, Nanjing 210037, P. R. China

Abstract

Alle Artikel dieser Rubrik

Abstract

Sulfonyl fluorides, due to their balanced potential reactivity and stability as well as their compatibility with biological systems, have become important synthetic intermediates and building blocks in the fields of organic synthesis, drug discovery, and materials science. Especially after the report of sulfur(VI) fluoride exchange (SuFEx) chemistry by Sharpless and others, research on sulfonyl fluoride compounds and related compounds has increased significantly. This review summarizes application of sulfonyl fluorides in organic synthesis in the period 2014–2024, discussing different types of organic reactions, including C–X bond formation (including C–C, C–N, and C–F bond formation etc.), S–C bond formation, S–N bond formation, S–O bond formation, multicomponent ‘one-pot’ synthesis, and cyclization.

1 Introduction

2 Sulfonyl Fluorides Applied in C–X (C, N, F) Bond Formation

3 Sulfonyl Fluorides Applied in S–C Bond Formation

4 Sulfonyl Fluorides Applied in S–N Bond Formation

5 Sulfonyl Fluorides Applied in S–O Bond Formation

6 Sulfonyl Fluorides Applied in Multicomponent Reactions

7 Sulfonyl Fluorides Applied in Cyclizations

8 Conclusion and Perspective

Key words

sulfonyl fluorides - SuFEx chemistry - C–X bond formation - S–X bond formation - multicomponent reaction - cyclization

Volltext

Referenzen

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