Nickel(II)-Catalyzed Cycloisomerization of 1,6-Dienes

Zhongjian Du; Chenlei Ji; Xu Wang; Sijian Zhang; Zhenyu Wang; Yang'en You

doi:10.1055/a-2508-3790

Synthesis, Table of Contents

Synthesis 2025; 57(07): 1306-1312
DOI: 10.1055/a-2508-3790

psp

Nickel(II)-Catalyzed Cycloisomerization of 1,6-Dienes

Authors

Zhongjian Du‡

^aSchool of Chemistry and Chemical Engineering, Hefei University of Technology and Anhui Province Key Laboratory of Value-Added Catalytic Conversion and Reaction Engineering, Hefei 230009, P. R. of China
Chenlei Ji‡

^aSchool of Chemistry and Chemical Engineering, Hefei University of Technology and Anhui Province Key Laboratory of Value-Added Catalytic Conversion and Reaction Engineering, Hefei 230009, P. R. of China
Xu Wang

^aSchool of Chemistry and Chemical Engineering, Hefei University of Technology and Anhui Province Key Laboratory of Value-Added Catalytic Conversion and Reaction Engineering, Hefei 230009, P. R. of China
Sijian Zhang

^aSchool of Chemistry and Chemical Engineering, Hefei University of Technology and Anhui Province Key Laboratory of Value-Added Catalytic Conversion and Reaction Engineering, Hefei 230009, P. R. of China
Zhenyu Wang

^bAnhui Province Key Lab of Green Manufacturing in Phosegene Industry, Caijiashan Fine Chem Pk, Xinhang 242235, P. R. of China
Yang'en You

^aSchool of Chemistry and Chemical Engineering, Hefei University of Technology and Anhui Province Key Laboratory of Value-Added Catalytic Conversion and Reaction Engineering, Hefei 230009, P. R. of China

Abstract

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Abstract

A nickel-catalyzed protocol for the cycloisomerization of 1,6-dienes has been developed. Using commercially available NiBr₂ and PPh₃ as catalysts, Zn as a reductant, and ZnI₂ as an additive, the methodology efficiently converts various 1,6-dienes into pyrrolidine derivatives in excellent yields and high selectivity.

Key words

nickel-catalyzed - 1,6-dienes - cycloisomerization - pyrrolidine derivatives

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References

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Supplementary Material

Supporting Information (PDF)