Open Access
CC BY 4.0 · Ultrasound Int Open 2025; 11: a25131054
DOI: 10.1055/a-2513-1054
Original Article

Analysis of correlation between dynamic contrast-enhanced ultrasound and angiogenesis activity of renal cell carcinoma

Xiuyun Lu
1   Ultrasound, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China (Ringgold ID: RIN91603)
,
Jianqing Ye
2   Urology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China (Ringgold ID: RIN91603)
,
Xiuwu Pan
2   Urology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China (Ringgold ID: RIN91603)
,
Shaojun Chen
2   Urology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China (Ringgold ID: RIN91603)
,
Liang Zhang
2   Urology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China (Ringgold ID: RIN91603)
,
Ying Wang
1   Ultrasound, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China (Ringgold ID: RIN91603)
,
Juan Cheng
1   Ultrasound, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China (Ringgold ID: RIN91603)
,
Jiaying Cao
1   Ultrasound, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China (Ringgold ID: RIN91603)
,
Li Wei
1   Ultrasound, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China (Ringgold ID: RIN91603)
,
Xingang Cui
2   Urology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China (Ringgold ID: RIN91603)
,
1   Ultrasound, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China (Ringgold ID: RIN91603)
› Institutsangaben

Gefördert durch: Sino-German Mobility Programme of NSFC and DFG M-0504
Gefördert durch: National Natural Science Foundation of China 82071942,82272013
Gefördert durch: Shanghai Pujiang Program 2020PJD008
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Abstract

Purpose

To investigate the potential correlation of dynamic contrast-enhanced ultrasound (DCE-US) with angiogenesis activity of renal cell carcinoma (RCC).

Materials and Methods

Patients with surgery resection and histopathologically proven RCC lesions were included. B-mode ultrasound (BMUS) and contrast-enhanced ultrasound (CEUS) were performed one week before surgery. SonoVue was injected as the contrast agent. VueBox (Bracco, Italy) was used for the quantitative analysis. According to the histopathological and immunohistochemical results, patients were classified into two groups: active angiogenesis and inactive angiogenesis. Time intensity curves (TICs) and quantitative parameters were compared between two groups.

Results

From July 2023 to November 2023, a total of 50 patients (13 females and 37 males, mean age 61.1±11.1 years) were included. The mean size of the lesions was 39.4±2.7 mm. Patients were classified into the active angiogenesis group (n=30) and the inactive angiogenesis group (n=20). On BMUS, 68.0% (34/50) of RCCs were visualized as hypoechoic lesions with ill-defined borders and irregular shapes (P>0.05). During cortical phase of CEUS, 72.6% (23/30) of RCCs with active angiogenesis were visualized with hyperenhancement (P=0.027). Only 30.0% (9/30) of RCCs with active angiogenesis showed hypo-enhancement in the parenchymal phase (P>0.05). Compared to the inactive angiogenesis group, TICs of the active angiogenesis group revealed faster and greater enhancement in the cortical phase, slower decline during the parenchymal phase, and an increased area under the curve. Among quantitative parameters, the active angiogenesis group showed the higher ratio of wash-in rate and wash-in perfusion index (P<0.05).

Conclusion

DCE-US analysis has potential value in predicting angiogenesis activity in RCC lesions.



Publikationsverlauf

Eingereicht: 04. Juli 2024

Angenommen nach Revision: 05. Januar 2025

Artikel online veröffentlicht:
15. September 2025

© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/).

Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany

Bibliographical Record
Xiuyun Lu, Jianqing Ye, Xiuwu Pan, Shaojun Chen, Liang Zhang, Ying Wang, Juan Cheng, Jiaying Cao, Li Wei, Xingang Cui, Yi Dong. Analysis of correlation between dynamic contrast-enhanced ultrasound and angiogenesis activity of renal cell carcinoma. Ultrasound Int Open 2025; 11: a25131054.
DOI: 10.1055/a-2513-1054
 
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