Abstract
Alzheimer’s disease (AD) comes under progressive neurodegenerative disorders which
is the leading cause of dementia affecting the aged population. The available drugs
for AD treatment are just palliative and not curative, further these drugs have severe
side effects. Therefore, there is a significant demand for novel, potent, and safe
molecules as anti-Alzheimer’s disease agents with diverse mechanisms of action. Benzofuran
derivatives are one of the versatile and ubiquitous scaffolds being developed as potential
candidates against AD. While benzofuran analogues have not yet resulted in widely
approved AD treatments, these molecules remain a significant focus of AD drug discovery
because of their multitargeted approach and promising preclinical results. The ongoing
research into these molecules holds potential for future clinical applications as
anti-AD agents. In light of this, the present review outlined recent advances of the
synthesis and potent anti-AD activities reported. The sole purpose of this review
is to shed light on the design and development of these molecules with high efficacy
and reduced toxicity against AD.
1 Introduction
2 Synthesis
3 Benzofuran-Based Scaffolds against AD
4 Naturally Occurring Benzofurans for Treatment of AD
5 Future Perspectives
6 Conclusion
Key words
benzofuran - synthesis - electrochemical - Alzheimer’s disease - AChE - β-amyloid
