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CC BY-NC-ND 4.0 · Geburtshilfe Frauenheilkd 2025; 85(05): 493-506
DOI: 10.1055/a-2533-2783
GebFra Science
Review

Update Mammakarzinom 2024 Teil 2 – Patientinnen mit Frühstadien des Mammakarzinoms

Article in several languages: English | deutsch
Wolfgang Janni
1   Department of Gynecology and Obstetrics, Ulm University Hospital, Ulm, Germany
,
Hans-Christian Kolberg
2   Department of Gynecology and Obstetrics, Marienhospital Bottrop, Bottrop, Germany
,
Andreas D. Hartkopf
3   Department of Gynecology and Obstetrics, Tübingen University Hospital, Tübingen, Germany
,
Tanja N. Fehm
4   Department of Gynecology and Obstetrics, University Hospital Düsseldorf, Düsseldorf, Germany
5   Center for Integrated Oncology (CIO Aachen, Bonn, Cologne, Düsseldorf), Düsseldorf, Germany
,
Manfred Welslau
6   Onkologie Aschaffenburg, Aschaffenburg, Germany
,
Volkmar Müller
7   Department of Gynecology, Hamburg-Eppendorf University Medical Center, Hamburg, Germany
,
Florian Schütz
8   Gynäkologie und Geburtshilfe, Diakonissen-Stiftungs-Krankenhaus, Speyer, Germany
,
Peter A. Fasching
9   Department of Gynecology and Obstetrics, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany
10   Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Erlangen, Germany
,
Christian Jackisch
11   Evangelische Kliniken Essen Mitte, Essen, Germany
,
Frederik Marme
12   Universitätsmedizin Mannheim, Frauenklinik, Mannheim, Germany
,
Manuel Hörner
9   Department of Gynecology and Obstetrics, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany
10   Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Erlangen, Germany
,
Katharina Keller
9   Department of Gynecology and Obstetrics, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany
10   Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Erlangen, Germany
,
Chloë Goossens
9   Department of Gynecology and Obstetrics, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany
10   Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Erlangen, Germany
,
Erik Belleville
13   ClinSol GmbH & Co. KG, Würzburg, Germany
,
Michael Untch
14   Clinic for Gynecology and Obstetrics, Breast Cancer Center, Gynecologic Oncology Center, Helios Klinikum Berlin Buch, Berlin, Germany
,
Marc Thill
15   Agaplesion Markus Krankenhaus, Department of Gynecology and Gynecological Oncology, Frankfurt am Main, Germany
,
Hans Tesch
16   Oncology Practice at Bethanien Hospital, Frankfurt am Main, Germany
,
Nina Ditsch
17   Department of Gynecology and Obstetrics, University Hospital Augsburg, Augsburg, Germany
,
Michael P. Lux
18   Klinik für Gynäkologie und Geburtshilfe, Frauenklinik St. Louise, Paderborn, St. Josefs-Krankenhaus, Salzkotten, St. Vincenz Krankenhaus GmbH, Paderborn, Germany
,
Maggie Banys-Paluchowski
19   Department of Gynecology and Obstetrics, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany
,
Achim Wöckel
20   Department of Gynecology and Obstetrics, University Hospital Würzburg, Würzburg, Germany
,
Nadia Harbeck
21   Breast Center, Department of Gynecology and Obstetrics and CCC Munich LMU, LMU University Hospital, Munich, Germany
,
Elmar Stickeler
22   Department of Obstetrics and Gynecology, Center for Integrated Oncology (CIO Aachen, Bonn, Cologne, Düsseldorf), University Hospital of RWTH Aachen, Aachen, Germany
,
Rupert Bartsch
23   Department of Medicine I, Division of Oncology, Medical University of Vienna, Vienna, Austria
,
Bahriye Aktas
24   Department of Gynecology, University of Leipzig Medical Center, Leipzig, Germany
,
Andreas Schneeweiss
25   National Center for Tumor Diseases, University Hospital and German Cancer Research Center, Heidelberg, Germany
,
Johannes Ettl
26   Cancer Center Kempten/Allgäu, Klinikverbund Allgäu gGmbH, Department of Obstetrics and Gynecology and Department of Oncology and Palliative Care, Klinikverbund Allgäu, Klinik für Frauenheilkunde und Gynäkologie, Kempten, Germany
,
Florin-Andrei Taran
27   Department of Gynecology and Obstetrics, University Hospital Freiburg, Freiburg, Germany
,
Diana Lüftner
28   Immanuel Hospital Märkische Schweiz, Buckow, Germany & Medical University of Brandenburg Theodor-Fontane, Brandenburg, Germany
,
Rachel Würstlein
21   Breast Center, Department of Gynecology and Obstetrics and CCC Munich LMU, LMU University Hospital, Munich, Germany
,
Julia C. Radosa
29   Department of Gynecology and Obstetrics, Saarland University Hospital, Homburg, Germany
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Zusammenfassung

Diese Übersichtsarbeit fasst die aktuellen Entwicklungen zur Behandlung von Patientinnen mit Frühstadien des Mammakarzinoms zusammen. Die meisten klinisch relevanten Veränderungen sind durch die Einführung der Immuncheckpoint-Inhibitoren bei Patientinnen mit triple-negativem Brusktrebs (TNBC) und der CDK4/6-Inhibitoren bei Patientinnen mit Hormonrezeptor-positiven, HER2-negativen (HRpos/HER2neg) Tumoren und hohem Rückfallrisiko vollzogen worden. Hier entstehen zunehmend Daten mit einer längeren Nachbeobachtungszeit und Integration von translationalen Analysen, die neue Biomarker wie zirkulierende Tumor-DNA (ctDNA) bewerten. In dieser Übersichtsarbeit werden die neuesten Entwicklungen der letzten Monate zusammengefasst und in den jeweiligen Kontext eingeordnet.

Schlüsselwörter

Mammakarzinom - Biomarker - klinische Studien - frühes Mammakarzinom


Publication History

Received: 20 November 2024

Accepted after revision: 07 December 2024

Article published online:
15 May 2025

© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany

 

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