Nahrungsergänzungsmittel unter psychosomatischer Betrachtung

Nahrungsergänzungsmittel haben ihren Einsatz längst nicht mehr nur im Kontext einer Mangelprophylaxe. Vielmehr zeichnen sich differenzierte Einsatzmöglichkeiten ab, insbesondere bei Patientengruppen mit spezifischen somatischen oder psychischen Erkrankungen. Erkenntnisse aus der Ernährungswissenschaft, Psychiatrie und Inneren Medizin werden zunehmend zusammen betrachtet und können in eine individualisierte Therapie münden.

Publication History

Article published online:
11 December 2025

• Literatur

• 1 Bellows L, Moore R, Anderson J, Young L. Water-soluble vitamins: B-complex and vitamin C. Food and nutrition series. Health 2012; 9: 312
• 2 Akram M, Munir N, Daniyal M. et al. Vitamins and Minerals: Types, Sources and their Functions. In: Egbuna C, Dable Tupas G, eds. Functional Foods and Nutraceuticals: Bioactive Components, Formulations and Innovations [Internet]. Cham: Springer International Publishing; 2020: 149-172 Zugriff am 02.06.2025 unter:
• 3 Schoon D. Mangelernährung durch Foodtrends und Diäten. Ernährung & Medizin 2025; 40: 7-13
• 4 Lal R. Soil degradation as a reason for inadequate human nutrition. Food Sec 2009; 1: 45-57
• 5 Zyriax BC, Windler E. Welche Nahrungsergänzungsmittel braucht die Frau nach der Menopause?. Journal für Gynäkologische Endokrinologie 2012; 6: 5-11
• 6 Ismail O, Albdour K, Albdour Z, Jaber K. Differences in ferritin, vitamin D, and vitamin B12 between fibromyalgia patients and healthy individuals: A systematic review and meta-analysis. Musculoskeletal Care 2025; 23: e70057
• 7 Cheng YC, Huang WL, Chen WY. et al. Comparative efficacy and tolerability of nutraceuticals for depressive disorder: A systematic review and network meta-analysis. Psychol Med 2025; 55: e134
• 8 Dumbre D, Upendra S, Zacharias BS. Unraveling the relationship between vitamin D and noncommunicable diseases: A systemic review and meta-analysis. Public Health Nursing 2025; 42: 1302-1314
• 9 He J, Gao Z, Li X, Zhao L. et al. Systematic review of optimizing brain-targeted vitamin D delivery: Novel approaches to enhance mental illness therapeutics. Brain Res 2025; 1858: 149656
• 10 Heilmeyer L, Begemann H. Lehrbuch der inneren Medizin. Berlin, Heidelberg: Springer; 1955. 1326.
• 11 Coulbault L, Ritz L, Vabret F. et al. Thiamine and phosphate esters concentrations in whole blood and serum of patients with alcohol use disorder: a relation with cognitive deficits. Nutr Neurosci 2021; 24: 530-541
• 12 Teixeira J, Pereira I, Castanho M, do Couto FS. What is the impact of thiamine deficiency on cognitive function in patients with alcohol use disorder? A systematic review. Eur J Intern Med 2025; 134: 59-65
• 13 Wang M, Fang M, Zang W. Effects of folic acid supplementation on cognitive function and inflammation in elderly patients with mild cognitive impairment: A systematic review and meta-analysis of randomized controlled trials. Arch Gerontol Geriatr 2024; 126: 105540
• 14 Marwaha S, Agarwal R, Tripathi M, Tripathi S. Unlocking the vitamin puzzle: Investigating levels in people with Alzheimer’s disease versus healthy controls through systematic review and network meta-analysis. J Hum Nutr Diet 2025; 38: e70007
• 15 Vollset SE, Clarke R, Lewington S. et al. Effects of folic acid supplementation on overall and site-specific cancer incidence during the randomised trials: meta-analyses of data on 50,000 individuals. Lancet 2013; 381: 1029-1036
• 16 Borges-Vieira JG, Cardoso CKS. Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials. Nutr Neurosci 2023; 26: 187-207
• 17 Yan S, Liu H, Yu Y. et al. Changes of serum homocysteine and vitamin B12, but not folate are correlated with obsessive-compulsive disorder: A systematic review and meta-analysis of case-control studies. Front Psychiatry 2022; 13: 754165
• 18 González-Parejo P, Martín-Núñez J, Cabrera-Martos I, Valenza MC. Effects of dietary supplementation in patients with restless legs syndrome: A systematic review. Nutrients 2024; 16: 2315
• 19 Ji X, Grandner MA, Liu J. The relationship between micronutrient status and sleep patterns: a systematic review. Public Health Nutr 2017; 20: 687-701
• 20 Nault D, Machingo TA, Shipper AG. et al. Zinc for prevention and treatment of the common cold. Cochrane Database Syst Rev 2024; 5: CD014914
• 21 Te L, Liu J, Ma J, Wang S. Correlation between serum zinc and testosterone: A systematic review. J Trace Elem Med Biol 2023; 76: 127124
• 22 Morgado A, Tsampoukas G, Sokolakis I. et al. Do „testosterone boosters“ really increase serum total testosterone? A systematic review. Int J Impot Res 2024; 36: 348-364
• 23 Kunugi H. Depression and lifestyle: Focusing on nutrition, exercise, and their possible relevance to molecular mechanisms. Psych. Clin Neurosci 2023; 77: 420-433
• 24 Kodama H, Tanaka M, Naito Y. et al. Japan’s Practical Guidelines for zinc deficiency with a particular focus on taste disorders, inflammatory bowel disease, and liver cirrhosis. Int J Mol Sci 2020; 21: 2941
• 25 Maes M, D’Haese PC, Scharpé S. et al. Hypozincemia in depression. J Affect Disord 1994; 31: 135-140
• 26 Wang Z, Qiu B, Li R. et al. Effects of creatine supplementation and resistance training on muscle strength gains in adults < 50 years of age: A systematic review and meta-analysis. Nutrients 2024; 16: 3665
• 27 Lyoo IK, Yoon S, Kim TS. et al. A randomized, double-blind placebo-controlled trial of oral creatine monohydrate augmentation for enhanced response to a selective serotonin reuptake inhibitor in women with major depressive disorder. Am J Psychiatry 2012; 169: 937-945
• 28 Sarris J, Ravindran A, Yatham LN. et al. Clinician guidelines for the treatment of psychiatric disorders with nutraceuticals and phytoceuticals: The World Federation of Societies of Biological Psychiatry (WFSBP) and Canadian Network for Mood and Anxiety Treatments (CANMAT) Taskforce. World J Biol Psychiatry 2022; 23: 424-455
• 29 EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA). Turck D, Bohn T, Cámara M. et al. Creatine and improvement in cognitive function: Evaluation of a health claim pursuant to article 13(5) of regulation (EC) No 1924/2006. EFSA Journal 2024; 22: e9100
• 30 Raghu G, Berk M, Campochiaro PA. et al. The multifaceted therapeutic role of N-acetylcysteine (NAC) in disorders characterized by oxidative stress. Curr Neuropharmacol 2021; 19: 1202-1224
• 31 Suh SW, Lim E, Burm SY. et al. The influence of n-3 polyunsaturated fatty acids on cognitive function in individuals without dementia: a systematic review and dose-response meta-analysis. BMC Med 2024; 22: 109
• 32 Shen D, Zhang X, Li Z, Bai H, Chen L. Effects of omega-3 fatty acids on bone turnover markers in postmenopausal women: systematic review and meta-analysis. Climacteric 2017; 20: 522-527
• 33 Wylenzek F, Bühling KJ, Laakmann E. A systematic review on the impact of nutrition and possible supplementation on the deficiency of vitamin complexes, iron, omega-3-fatty acids, and lycopene in relation to increased morbidity in women after menopause. Arch Gynecol Obstet 2024; 310: 2235-2245
• 34 Sarris J, Murphy J, Mischoulon D. et al. Adjunctive nutraceuticals for depression: A systematic review and meta-analyses. AJP 2016; 173: 575-587
• 35 Soeken KL, Lee WL, Bausell RB. et al. Safety and efficacy of S-adenosylmethionine (SAMe) for osteoarthritis. J Fam Pract 2002; 51: 425-430
• 36 Baden KER, McClain H, Craig E. et al. S-Adenosylmethionine (SAMe) for liver health: A systematic review. Nutrients 2024; 16: 3668