Efficacy of Homeopathic Complexes in Gastrointestinal Nematode Control in Sheep

Abstract

Background

Gastrointestinal worm infestation, mainly by H. contortus, represents one of the main health challenges in sheep farming, exacerbated by resistance to conventional anthelmintics. This study evaluated the efficacy of two homeopathic complex formulations in reducing parasite load in ewes (not lactating/not pregnant) over a period of 45 days.

Methods

Thirty Santa Inês and Dorper crossbred sheep were used, distributed in three treatments: T1 (Apis mellifica 15cH + Arsenicum album 11cH + Cina 9cH + Kalium phosphoricum 15cH + Spigelia anthelmia 9cH + Pereskia aculeata 6cH), T2 (the constituents of T1 but replacing Pereskia aculeata by Ferrum metallicum 6cH) and T3 (control group, without homeopathic treatment). The animals were evaluated by counting the EPG (eggs per gram of feces), monitoring level of anemia by the grade of ocular mucosal coloration (FAMACHA^® method) and measuring body weight on each of days 0, 15, 30 and 45.

Results

The results showed a significant (p < 0.05) decline in EPG from the 30th day, being more pronounced in group T2, which showed 79% efficacy on the 45th day. There were no significant differences between the treatments related to FAMACHA^® score or daily weight gain.

Conclusion

The homeopathic complexes used in this study, particularly T2 which contains Ferrum metallicum 6cH, contributed to the control of gastrointestinal nematode infection in dry ewes.

Keywords

gastrointestinal nematodes - Haemonchus contortus - homeopathy - sheep

Publikationsverlauf

Eingereicht: 18. Dezember 2024

Angenommen: 17. März 2025

Artikel online veröffentlicht:
28. August 2025

• References

• 1 Mena MO, Trevise GGO, Silva TNR. et al. Evaluation of grape pomace supplementation in lamb diets to mitigate Haemonchus contortus infection. Agriculture 2025; 15: 341
• 2 Li X, Xiang H, Liang R. et al. Tannin alleviated reproductive dysfunction in pregnant ewes infected with Haemonchus contortus . Front Vet Sci 2025; 12: 1531233
• 3 Torres-Acosta JFJ, Mendoza-de-Gives P, Aguilar-Caballero AJ, Cuéllar-Ordaz JA. Anthelmintic resistance in sheep farms: update of the situation in the American continent. Vet Parasitol 2012; 189: 89-96
• 4 Rose H, Rinaldi L, Bosco A. et al. Widespread anthelmintic resistance in European farmed ruminants: a systematic review. Vet Rec 2015; 176: 546
• 5 Wang C, Li F, Zhang Z. et al. Recent research progress in China on Haemonchus contortus . Front Microbiol 2017; 8: 1509
• 6 Qamar W, Alkheraiije KA. Anthelmintic resistance in Haemonchus contortus of sheep and goats from Asia – a review of in vitro and in vivo studies. Pak Vet J 2023; 43: 376-387
• 7 Giuliotti L, Pisseri F, Sarsina PR. et al. Gastrointestinal strongyles burden monitoring in a flock of Zerasca sheep treated with homeopathy. Eur J Integr Med 2016; 8: 235-238
• 8 Bellavite P, Ortolani R, Pontarollo F, Pitari G, Conforti A. Immunology and homeopathy. 5. The rationale of the ‘Simile’. Evid Based Complement Alternat Med 2007; 4: 149-163
• 9 Pustiglione M. Organon da arte de curar de Samuel Hahnemann para o século XXI. São Paulo: Organon; 2021
• 10 Boon H, Verhoef M, O'Hara D, Findlay B, Majid N. Integrative healthcare: arriving at a working definition. Altern Ther Health Med 2004; 10: 48-56
• 11 Issautier MN. Fundamentals of homeopathy and principles of use in cattle. Point Vét 2016; 47: 51-57
• 12 Rubio VGG, Carrasco JJO. Homeopathic veterinary medicine as an alternative treatment in ruminants. In: Abbas RZ. et al., eds. Complementary and Alternative Medicine: Botanicals/Homeopathy/Herbal Medicine. Faisalabad: Unique Scientific Publishers; 2024: 273-281
• 13 Tripathi U, Bahurupi Y, Jasrotia A. Integration of homeopathy in one health. J Compr Health 2024; 2: 6-10
• 14 Hadipour MM, Habibi GH, Ghorashinejad A. et al. Evaluation of the homeopathic remedies medication on commercial broiler chickens performance. J Anim Vet Adv 2011; 10: 2102-2105
• 15 Asghar F, Khan MZ, Ahsan M. et al. Role of homeopathic medicines for gastrointestinal nematode control in animals. In: Abbas RZ. et al., eds. Complementary and Alternative Medicine: Botanicals/Homeopathy/Herbal Medicine. Faisalabad: Unique Scientific Publishers; 2024: 292-300
• 16 Lorenzini G, Martinii A, Sabatini L. et al. Efficiency and costs of the health management in an organic dairy farm where we use unconventional medicines. Ital J Anim Sci 2009; 8: 622-624
• 17 Correoso CC, Agostinho F, Smaniotto JR. et al. Sustainability assessment of family agricultural properties: the importance of homeopathy. Sustainability 2022; 14: 6334
• 18 Farmacopéia Homeopática Brasileira. 3rd ed.. ANVISA; 2022. . Accessed August 14, 2022 at: https://www.gov.br/anvisa/pt-br/assuntos/farmacopeia/farmacopeia-homeopatica/arquivos/8048json-file-1
• 19 Demarque D, Jouanny J, Poitevin B, Saint-Jean Y. Farmacologia & Matéria Médica Homeopática. São Paulo: Organon; 2019
• 20 Ueno H, Gonçalves PC. Manual para diagnóstico das helmintoses de ruminantes. 4th ed.. Tokyo: Japan International Cooperation Agency; 1998
• 21 Wursthorn L, Martin P. Reso: faecal egg count reduction test (FECRT) Analysis Program. 2.01. Parkville: CSIRO Animal Health Research Laboratory; 1990
• 22 van Wyk JA, Bath GF. The FAMACHA system for managing haemonchosis in sheep and goats by clinically identifying individual animals for treatment. Vet Res 2002; 33: 509-529
• 23 Kenyon P, Maloney S, Blache D. Review of sheep body condition score in relation to production characteristics. N Z J Agric Res 2014; 57: 38-64
• 24 SAS Institute. SAS/STAT software: Changes and enhancements through release 8.02. Cary: Statistical Analysis System Institute; 2001
• 25 Wolfinger R. Covariance structure selection in general mixed models. Commun Stat 1993; 22: 1079-1106
• 26 Veríssimo CJ, Niciura SCM, Alberti ALL. et al. Multidrug and multispecies resistance in sheep flocks from São Paulo state, Brazil. Vet Parasitol 2012; 187: 209-216
• 27 Bassetto CC, Albuquerque ACA, Lins JGG. et al. Revisiting anthelmintic resistance in sheep flocks from São Paulo State, Brazil. Int J Parasitol Drugs Drug Resist 2024; 24: 100527
• 28 Salgado JA, Santos CdeP. Overview of anthelmintic resistance of gastrointestinal nematodes of small ruminants in Brazil. Rev Bras Parasitol Vet 2016; 25: 3-17
• 29 Amarante AFT. Sustainable worm control practices in South America. Small Rumin Res 2014; 118: 56-62
• 30 Bueno MS, Cunha EA, Verissimo CJ. et al. Infección por nematodos em razas de ovejas cárnicas criadas intensivamente en la región del sudeste del Brasil. Arch Zootec 2002; 51: 271-278
• 31 Duprat H. Teoría y Técnica Homeopáticas. Puebla, México: Publicaciones “Homeopatía Científica”; 1937
• 32 Lins JGG, Albuquerque ACA, Almeida FA. et al. Abomasal RNA-seq reveals a strong local cellular response in suckling lambs with resistance against Haemonchus contortus . Int J Parasitol 2023; 53: 739-749
• 33 Gupta VK, Mathur M. Immunomodulatory effects of homeopathic medicines: a review of pre-clinical studies. Indian J Res Homoeopathy 2018; 12: 90-94
• 34 Zacharias F, Guimarães JE, Araújo RR. et al. Effect of homeopathic medicines on helminth parasitism and resistance of Haemonchus contortus infected sheep. Homeopathy 2008; 97: 145-151
• 35 Cavalcanti ASR, Almeida MAO, Dias AVS. Effect of homeopathic drugs on the numbers of nematode eggs in faeces (FEC) and on the body weight gain of sheep. Rev Bras Saude Prod Anim 2007; 8: 162-169
• 36 Assis LM, Bevilaqua CML, Morais SM, Vieira LS, Costa CTC, Souza JAL. Ovicidal and larvicidal activity in vitro of Spigelia anthelmia Linn. extracts on Haemonchus contortus . Vet Parasitol 2003; 117: 43-49
• 37 Higuera-Piedrahita RI, López-Arellano ME, López-Arellano R, Cuenca-Verde C, Cuéllar-Ordaz JA. Artemisia cina 30 CH como tratamiento homeopático contra el Haemonchus contortus . Rev Mex Cienc Pecu 2020; 11: 342-354
• 38 Qamar MF, Maqbool A, Ahmad N. Comparative efficacy of allopathic, herbal, homeopathic and effective micro-organisms for the control of haemonchosis in sheep & goats. Sci Int (Lahore) 2011; 23: 43-48
• 39 Neves HH, Hotzel MJ, Honorato LA. et al. Controle de verminoses gastrintestinais em caprinos utilizando preparados homeopáticos. Rev Bras Agroecol 2012; 7: 145-151
• 40 Falbo MK, Santos SK, Pivatto DRD, Padilha JB, Carneiro HG. Efeito da homeopatia no controle da verminose em ovinos. In: Memorias. VIII Congreso Latinoamericano de Especialistas en Pequeños Rumiantes y Camélidos Sudamericanos; 2013: 84-87
• 41 Pacheco PA, Marconato MN, Dos Reis LL, Katiki LM, de Paz CCP, da Costa RLD. Evaluation of parasitological homeopathic complex in the control of gastrointestinal nematodes in peripartum sheep. Homeopathy 2019; 108: 248-255
• 42 Chagas ACS, Vieira LS, Freitas ARR. et al. Anthelmintic efficacy of neem (Azadirachta indica A. Juss) and the homeopathic product Fator Vermes in Morada Nova sheep. Vet Parasitol 2008; 151: 68-73
• 43 da Rocha RA, Pacheco RDL, Amarante AFT. Efficacy of homeopathic treatment against natural infection of sheep by gastrointestinal nematodes. Rev Bras Parasitol Vet 2006; 15: 23-27