A stereoselective synthesis of deuterated oxazoloisoindolinones using D2O was achieved
through photocatalytic deoxygenation of readily available N-phthalimide amino acids,
followed by an intramolecular 5-endo-trig cyclization. This protocol provides an efficient
access to a broad array of deuterium-labeled N,O-heterobicycles with excellent deuterium
incorporation.
