Magenschrittmacher-Update: Relevanz bei Gastroparese

Johannes Riebeling; Robert Patejdl; David Zipf; Lena-Christin Conradi; Michael Ghadimi; Felix Gundling; Tobias Bruegmann

doi:10.1055/a-2636-2851

Zentralblatt für Chirurgie - Zeitschrift für Allgemeine, Viszeral-, Thorax- und Gefäßchirurgie, Table of Contents

Zentralbl Chir 2025; 150(04): 337-345
DOI: 10.1055/a-2636-2851

Übersicht

Magenschrittmacher-Update: Relevanz bei Gastroparese

Update on Gastric Pacemaking: Relevance for Gastroparesis

Authors

Johannes Riebeling

¹Institut für Herz- und Kreislaufphysiologie, Universitätsmedizin Göttingen, Göttingen, Deutschland (Ringgold ID: RIN27177)

²Klinik für Allgemein-, Viszeral- und Kinderchirurgie, CHIR-Net Göttingen, Universitätsmedizin Göttingen, Göttingen, Deutschland (Ringgold ID: RIN155940)

³Else Kröner Fresenius Zentrum für optogenetische Therapien, Universitätsmedizin Göttingen, Göttingen, Deutschland (Ringgold ID: RIN27177)
Robert Patejdl

⁴Fakultät Medizin, HMU Health and Medical University Erfurt GmbH, Erfurt, Deutschland (Ringgold ID: RIN661195)
David Zipf

¹Institut für Herz- und Kreislaufphysiologie, Universitätsmedizin Göttingen, Göttingen, Deutschland (Ringgold ID: RIN27177)
Lena-Christin Conradi

²Klinik für Allgemein-, Viszeral- und Kinderchirurgie, CHIR-Net Göttingen, Universitätsmedizin Göttingen, Göttingen, Deutschland (Ringgold ID: RIN155940)

³Else Kröner Fresenius Zentrum für optogenetische Therapien, Universitätsmedizin Göttingen, Göttingen, Deutschland (Ringgold ID: RIN27177)
Michael Ghadimi

²Klinik für Allgemein-, Viszeral- und Kinderchirurgie, CHIR-Net Göttingen, Universitätsmedizin Göttingen, Göttingen, Deutschland (Ringgold ID: RIN155940)

³Else Kröner Fresenius Zentrum für optogenetische Therapien, Universitätsmedizin Göttingen, Göttingen, Deutschland (Ringgold ID: RIN27177)
Felix Gundling

⁵Medizinische Klinik II Gastroenterologie, Gastroenterologische Onkologie, Hepatologie, Diabetologie, Stoffwechsel, Infektiologie, Klinikum Bamberg Klinikum am Bruderwald, Bamberg, Deutschland (Ringgold ID: RIN646950)
Tobias Bruegmann

¹Institut für Herz- und Kreislaufphysiologie, Universitätsmedizin Göttingen, Göttingen, Deutschland (Ringgold ID: RIN27177)

³Else Kröner Fresenius Zentrum für optogenetische Therapien, Universitätsmedizin Göttingen, Göttingen, Deutschland (Ringgold ID: RIN27177)

⁶Exzellenzcluster „Multiscale Bioimaging: von molekularen Maschinen zu Netzwerken erregbarer Zellen“, Georg-August-Universität Göttingen, Göttingen, Deutschland (Ringgold ID: RIN9375)

Abstract

Zusammenfassung

Die Gastroparese stellt eine Erkrankung dar, bei der die Magenentleerung in Abwesenheit einer mechanischen Obstruktion des Magenausgangs erheblich eingeschränkt ist. Neben medikamentös-konservativen Maßnahmen stellt die gastrale Elektrostimulation (GES) bei refraktären Verläufen eine mögliche Therapiealternative dar. Allerdings lässt die Datenlage aus randomisierten kontrollierten Studien zur Wirksamkeit keine uneingeschränkte Empfehlung zu. Ziel dieser Übersichtsarbeit ist neben der Einführung in das Krankheitsbild der Gastroparese inkl. der zugrunde liegenden Pathophysiologie die Einordnung der therapeutischen Rolle der GES anhand der aktuell verfügbaren Literatur. Insbesondere werden Indikationen und Limitationen der Therapie aufgezeigt, bevor mögliche Optimierungen der Therapie skizziert und ein Ausblick auf ein mögliches innovatives Therapieverfahren in der Zukunft gegeben werden.

Abstract

Gastroparesis is a disease in which gastric emptying is significantly decreased in the absence of a mechanical obstruction of the gastric outlet. In addition to conservative or pharmacological treatment options, gastric electrical stimulation (GES) is a possible alternative therapy for refractory courses of the disease. However, the available data from randomised controlled trials on efficacy do not permit an unqualified recommendation. The aim of this review is to introduce the clinical picture of gastroparesis, including the underlying pathophysiology, and to classify the therapeutic role of GES, based on the currently available literature. In particular, indications and limitations of the therapy are outlined that may lead to optimisation of the therapy, followed by an outlook on a potential new therapeutic procedure.

Schlüsselwörter

Magenschrittmacher - gastrale Elektrostimulation - Gastroparese - Optogenetik

Keywords

gastric pacemaking - gastric electrical stimulation - gastroparesis - optogenetics

Full Text

References

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