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DOI: 10.1055/a-2649-0851
Ewing's Sarcoma of the Frontal Bone with Intracranial Extension
Abstract
Ewing's sarcoma, though rare, primarily affects children and young adults, commonly manifesting in long bones. Cranial involvement, particularly in the frontal bone, is exceptionally uncommon, posing diagnostic and therapeutic challenges. Meticulous pathological assessment is crucial for recognizing and managing such atypical presentations. A 16-year-old male presented with left frontal swelling and neurological symptoms. Imaging revealed a space-occupying lesion involving the left frontal bone with intracranial extension. Histopathology confirmed Ewing's sarcoma based on characteristic findings and positive immunohistochemical markers. Differential diagnoses include metastatic neuroblastoma, primitive neuroectodermal tumors, and chordomas, highlighting the importance of comprehensive evaluation. Ewing's sarcoma involving the skull necessitates a multidisciplinary approach for accurate diagnosis and management. This case underscores the significance of clinical, radiological, and pathological assessments in recognizing rare manifestations. Collaboration among teams is crucial for tailored management strategies and optimal patient outcomes.
Contributors' Statement
S.A. was accountable for the design and conceptualization of the study and writing the manuscript. S.M. was responsible for acquisition and interpretation of clinical data. C.A. was responsible for interpretation of data, and critically revising manuscript for important intellectual content. All authors read and approved the final manuscript.
Data Availability Statement
No new data were generated.
Ethical Approval
The study was done in accordance with the Declaration of Helsinki.
Informed Consent
Informed consent was taken from the guardian.
Publication History
Received: 04 February 2025
Accepted: 22 June 2025
Article published online:
14 July 2025
© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)
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