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DOI: 10.1055/a-2656-6413
Can a Rule-Based Expert System Diagnose Nasal Obstruction from Nasoendoscopy Videos?
Authors

Abstract
Introduction
Nasal obstruction has multiple causes requiring specialist endoscopy for diagnosis. A rule-based expert system (RB-ES), which applies five “if–then” rules based on nasal features, may help replicate ENT decision-making in settings with limited access.
Objectives & Hypotheses
This study evaluated RB-ES in diagnosing allergic rhinitis, chronic rhinosinusitis with (CRSwNP) and without (CRSsNP) nasal polyps, and deviated nasal septum. Primary outcomes were sensitivity and specificity; the secondary outcome was agreement with ENT specialists.
Study Design
Prospective cohort study.
Methods
Seventy-one participants (65 patients, 6 controls) underwent pre- and postdecongestion endoscopy. Four ENT specialists provided diagnoses. RB-ES performance was compared against confirmed clinical diagnoses.
Results
RB-ES showed no detectable significant sensitivity differences from ENT specialists (all p > 0.05). Sensitivity was highest for CRSwNP; specificity remained high overall.
Conclusion
RB-ES matched specialist performance in CRSwNP diagnosis. Dataset expansion and artificial intelligence integration are recommended for further validation.
Level of Evidence
II.
Declaration of GenAI Use
A generative AI tool (ChatGPT, OpenAI) was used exclusively for grammar and language refinement in this manuscript. No content generation, data analysis, or substantive intellectual contributions were made by the AI. The authors take full responsibility for the accuracy and integrity of the final text.
‡ Both are joint first authors and contributed equally to this article.
Publikationsverlauf
Accepted Manuscript online:
16. Juli 2025
Artikel online veröffentlicht:
28. Juli 2025
© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)
Thieme Medical Publishers, Inc.
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