Update Mammakarzinom 2024 Teil 2 – Patientinnen mit Frühstadien des Mammakarzinoms

Zusammenfassung

Diese Übersichtsarbeit fasst die aktuellen Entwicklungen zur Behandlung von Patientinnen mit Frühstadien des Mammakarzinoms zusammen. Die meisten klinisch relevanten Veränderungen sind durch die Einführung der Immuncheckpoint-Inhibitoren bei Patientinnen mit triple-negativem Brustkrebs (TNBC) und der CDK4/6-Inhibitoren bei Patientinnen mit hormonrezeptorpositiven, HER2-negativen (HRpos/HER2neg) Tumoren und hohem Rückfallrisiko vollzogen worden. Hier entstehen zunehmend Daten mit einer längeren Nachbeobachtungszeit und Integration von translationalen Analysen, die neue Biomarker wie zirkulierende Tumor-DNA (ctDNA) bewerten. In dieser Übersichtsarbeit werden die neuesten Entwicklungen der letzten Monate zusammengefasst und in den jeweiligen Kontext eingeordnet.

Abstract

This review summarizes the latest developments for the treatment of patients with early-stage breast cancer. Most of the clinically relevant changes were the result of using immune checkpoint inhibitors to treat patients with triple-negative breast cancer (TNBC) and CDK4/6 inhibitors to treat patients with hormone receptor-positive, HER2-negative (HRpos/HER2neg) tumors and a high risk of recurrence. Recent studies are presenting more and more data with long follow-up times and integrating translational analyses to evaluate new biomarkers such as circulating tumor DNA (ctDNA). This review article summarizes the latest developments published in recent months and puts the findings in context.

Schlüsselwörter

Mammakarzinom - Biomarker - klinische Studien - frühes Mammakarzinom

Keywords

breast cancer - biomarker - clinical studies - early breast cancer

Publication History

Received: 20 November 2024

Accepted after revision: 07 December 2024

Article published online:
24 September 2025

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