Subscribe to RSS
DOI: 10.1055/a-2661-9851
Aktuelles aus Diagnostik und Therapie der operativen Neurombehandlung
Current Advances in the Diagnosis and Surgical Treatment of Neuromas
Zusammenfassung
Symptomatische Neurome der oberen und unteren Extremität stellen nach Verletzung peripherer Nerven sowohl im Alltag wie auch im beruflichen Umfeld eine starke Beeinträchtigung für die Betroffenen dar. Klassische Herangehensweisen wie Neuromexzision oder auch konservative Therapieansätze standen bislang im Vordergrund. In den letzten Jahren konnte die periphere Nervenchirurgie jedoch durch Behandlungsoptionen wie Nervenrekonstruktionen mittels Allo-/Autograft, End-zu-Seit Neurorrhaphien, TMR (=Targeted Muscle Reinnerveration)-Operationen oder RPNI (=Regenerative Peripheral Nerve Interface)-Eingriffen in der Neuromtherapie erweitert werden (1).
Abstract
Symptomatic neuromas of the upper and lower extremities present significant challenges for affected individuals in both daily life and professional environments following peripheral nerve injuries. Traditional approaches, such as neuroma excision or conservative therapy methods, have so far predominated. In recent years, however, peripheral nerve surgery has expanded the therapeutic spectrum for neuroma treatment through approaches such as nerve reconstruction with allo-/autografts, end-to-side neurorrhaphy, targeted muscle reinnervation (TMR) surgery, and regenerative peripheral nerve interface (RPNI) procedures (1).
Schlüsselwörter
Chirurgie der peripheren Nerven - Neuromtherapie - Schmerz - Pathologie - Nervenrekonstruktion - HandchirurgiePublication History
Received: 28 July 2024
Accepted: 15 July 2025
Article published online:
17 September 2025
© 2025. Thieme. All rights reserved.
Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany
-
Literatur
- 1 Eberlin KR, Ducic I. Surgical Algorithm for Neuroma Management: A Changing Treatment Paradigm. Plast Reconstr Surg Glob Open 2018; 6: e1952
- 2 Vlot MA, Wilkens SC, Chen NC. et al. Symptomatic Neuroma Following Initial Amputation for Traumatic Digital Amputation. J Hand Surg Am 2018; 43: 86.e1-86.e8
- 3 Aman M, Mayrhofer-Schmid M, Schwarz D. et al. Avoiding scar tissue formation of peripheral nerves with the help of an acellular collagen matrix. PLoS One 2023; 18: e0289677
- 4 Arnold DMJ, Wilkens SC, Coert JH. et al. Diagnostic Criteria for Symptomatic Neuroma. Ann Plast Surg 2019; 82: 420-427
- 5 van der Avoort DJJC, Hovius SER, Selles RW. et al. The incidence of symptomatic neuroma in amputation and neurorrhaphy patients. J Plast Reconstr Aesthet Surg 2013; 66: 1330-1334
- 6 Restrepo-Garces CE, Marinov A, McHardy P. et al. Pulsed Radiofrequency Under Ultrasound Guidance for Persistent Stump-Neuroma Pain: Ultrasound Guided Pulsed Radiofrequency. Pain Pract 2011; 11: 98-102
- 7 Bennett MI, Simpson KH. Gabapentin in the treatment of neuropathic pain. Palliat Med 2004; 18: 5-11
- 8 Kolbenschlag J, Prahm C, Hurth H. et al. [Diagnostics and surgical treatment of painful neuromas]. Nervenarzt 2023; 94: 1106-1115
- 9 Prof. Harhaus, PD Dengler, Prof. Schwerdtfeger, Hrsg. S3-Leitlinie Versorgung peripherer Nervenverletzungen. 30092023 Version 2.1
- 10 Aman M, Glaser JJ, Boecker AH. et al. Hopeless Neuroma—The Neurotized Free Flap Tissue Augmentation as Salvage Therapy—A Concept and Clinical Demonstration. J Pers Med 2023; 13: 313
- 11 Dellon AL, Mackinnon SE. Treatment of the Painful Neuroma by Neuroma Resection and Muscle Implantation. Plast Reconstr Surg 1986; 77: 427-436
- 12 Dahlin LB, Wiberg M. Nerve injuries of the upper extremity and hand. EFORT Open Rev 2017; 2: 158-170
- 13 Vlot MA, Wilkens SC, Chen NC. et al. Symptomatic Neuroma Following Initial Amputation for Traumatic Digital Amputation. J Hand Surg Am 2018; 43: 86.e1-86.e8
- 14 Lu C, Sun X, Wang C. et al. Mechanisms and treatment of painful neuromas. Rev Neurosci 2018; 29: 557-566
- 15 Cohen S, Hsu E. Postamputation pain: epidemiology, mechanisms, and treatment. J Pain Res 2013; 6: 121
- 16 Rajput K, Reddy S, Shankar H. Painful Neuromas. Clin J Pain 2012; 28: 639-645
- 17 Lin EE, Horasek S, Agarwal S. et al. Local Administration of Norepinephrine in the Stump Evokes Dose-dependent Pain in Amputees. Clin J Pain 2006; 22: 482-486
- 18 Watson J, Gonzalez M, Romero A. et al. Neuromas of the Hand and Upper Extremity. J Hand Surg Am 2010; 35: 499-510
- 19 Stokvis A, Ruijs ACJ, van Neck JW. et al. Cold Intolerance in Surgically Treated Neuroma Patients: A Prospective Follow-Up Study. J Hand Surg Am 2009; 34: 1689-1695
- 20 Decrouy-Duruz V, Christen T, Raffoul W. Evaluation of surgical treatment for neuropathic pain from neuroma in patients with injured peripheral nerves. J Neurosurg 2018; 128: 1235-1240
- 21 Poyntz SA, Hacking NM, Dalal M. et al. Peripheral Interventions for Painful Stump Neuromas of the Lower Limb: A Systematic Review. Clin J Pain 2018; 34: 285-295
- 22 Ducic I, Mesbahi AN, Attinger CE. et al. The Role of Peripheral Nerve Surgery in the Treatment of Chronic Pain Associated with Amputation Stumps. Plast Reconstr Surg 2008; 121: 908-914
- 23 Brogan DM, Kakar S. Management of Neuromas of the Upper Extremity. Hand Clin 2013; 29: 409-420
- 24 Aydemir K, Demir Y, Güzelküçük Ü. et al. Ultrasound Findings of Young and Traumatic Amputees With Lower Extremity Residual Limb Pain in Turkey. Am J Phys Med Rehabil 2017; 96: 572-577
- 25 Aman M, Schwarz D, Stolle A. et al. Modern MRI Diagnostics of Upper-Extremity-Related Nerve Injuries—A Prospective Multi-Center Study Protocol for Diagnostics and Follow Up of Peripheral Nerve Injuries. J Pers Med 2022; 12: 1548
- 26 O’Reilly MAR, O’Reilly PMR, Sheahan JN. et al. Neuromas as the cause of pain in the residual limbs of amputees. An ultrasound study. Clin Radiol 2016; 71: 1068.e1-1068.e6
- 27 Chhabra A, Williams EH, Wang KC. et al. MR neurography of neuromas related to nerve injury and entrapment with surgical correlation. AJNR Am J Neuroradiol 2010; 31: 1363-1368
- 28 Van Der Avoort DJJC, Hovius SER, Selles RW. et al. The incidence of symptomatic neuroma in amputation and neurorrhaphy patients. J Plast Reconstr Aesthet Surg 2013; 66: 1330-1334
- 29 Abreu E, Aubert S, Wavreille G. et al. Peripheral tumor and tumor-like neurogenic lesions. Eur J Radiol 2013; 82: 38-50
- 30 Antoniadis G, Harhaus-Wähner L, Assmus H. Hrsg. Chirurgie peripherer Nerven kompakt. Berlin [Heidelberg]: Springer; 2021
- 31 Dellon AL, Aszmann OC. In musculus, veritas? Nerve “in muscle” versus targeted muscle reinnervation versus regenerative peripheral nerve interface: Historical review. Microsurgery 2020; 40: 516-522
- 32 Böcker A, Aman M, Kneser U. et al. Closing the Gap: Bridging Peripheral Sensory Nerve Defects with a Chitosan-Based Conduit a Randomized Prospective Clinical Trial. J Pers Med 2022; 12: 900
- 33 Moore AM, Kasukurthi R, Magill CK. et al. Limitations of Conduits in Peripheral Nerve Repairs. Hand (N Y) 2009; 4: 180-186
- 34 Hallgren A, Björkman A, Chemnitz A. et al. Subjective outcome related to donor site morbidity after sural nerve graft harvesting: a survey in 41 patients. BMC Surg 2013; 13: 39
- 35 Safa B, Jain S, Desai MJ. et al. Peripheral nerve repair throughout the body with processed nerve allografts: Results from a large multicenter study. Microsurgery 2020; 40: 527-537
- 36 Lans J, Eberlin KR, Evans PJ. et al. A Systematic Review and Meta-Analysis of Nerve Gap Repair: Comparative Effectiveness of Allografts, Autografts, and Conduits. Plast Reconstr Surg 2023; 151: 814e-827e
- 37 Mass DP, Ciano MC, Tortosa R. et al. Treatment of Painful Hand Neuromas by Their Transfer into Bone. Plast Reconstr Surg 1984; 74: 182-185
- 38 Prasetyono TOH, Permatasari E, Soetrisno E. Implantation of Nerve Stump Inside a Vein and a Muscle: Comparing Neuroma Formation in Rat. Int Surg 2014; 99: 807-811
- 39 González-Darder J, Barberá J, Abellán MJ. et al. Centrocentral anastomosis in the prevention and treatment of painful terminal neuroma: An experimental study in the rat. J Neurosurg 1985; 63: 754-758
- 40 Maslow JI, LeMone A, Scarola GT. et al. Digital Nerve Management and Neuroma Prevention in Hand Amputations. Hand (N Y) 2023; 18: 838-844
- 41 Sisti A, Uygur S, Lopez-Schultz SD. et al. Nerve Capping Techniques for Neuroma Management: A Comprehensive Literature Review. Ann Plast Surg 2024; 92: 106-119
- 42 Power D, Curtin C, Bellemère P. et al. Surgical Treatment of Symptomatic End-Neuroma With a New Bioresorbable Copolyester Nerve Capping Device: A Multicenter Prospective Cohort Study. Ann Plast Surg 2023; 91: 109-116
- 43 Isaacs J, Allen D, Chen LE. et al. Reverse End-to-Side Neurotization. J reconstr Microsurg 2005; 21: 43-48
- 44 Aman M, Festin C, Sporer ME. et al. Bionic reconstruction: Restoration of extremity function with osseointegrated and mind-controlled prostheses. Wien Klin Wochenschr 2019; 131: 599-607
- 45 Dumanian GA, Potter BK, Mioton LM. et al. Targeted Muscle Reinnervation Treats Neuroma and Phantom Pain in Major Limb Amputees: A Randomized Clinical Trial. Ann Surg 2019; 270: 238-246
- 46 Aman M, Biglari B, Thielen M. et al. An Algorithm for Elective Amputation Combined with Targeted Muscle Reinnervation in Complex Regional Pain Syndrome—A Perspective. J Pers Med 2022; 12: 1169
- 47 Goodyear EG, O’Brien AL, West JM. et al. Targeted Muscle Reinnervation at the Time of Amputation Decreases Recurrent Symptomatic Neuroma Formation. Plast Reconstr Surg 2024; 153: 154-163
- 48 Wu J, Chiu DT. Painful neuromas: a review of treatment modalities. Ann Plast Surg 1999; 43: 661-667