Abstract
Carbocycles/heterocycles are fundamental structural motifs in natural products, pharmaceuticals,
and functional materials. Alkyne-based cascade strategies have emerged as powerful
tools for the efficient construction of these frameworks, enabling rapid access to
diverse ring systems through domino cyclization pathways. This account highlights
the representative recent advances of alkyne-mediated cascade reactions, covering
transition-metal catalysis and acid-mediated reactions. These methods facilitate multiple
bond-forming events in a single operation, offering high atom and step economy. Special
focus is given to illustrative transformations, mechanistic insights, and the broad
utility of alkynes as precursors for the concise synthesis of diverse carbocyclic
and heterocyclic molecular frameworks.
Keywords
Carbocyclic - Heterocyclic - Domino - Cascade - Cyclization - Alkyne
