Heterogeneity of Lung Phagocytes and Clearance of Apoptotic Cells in Lung Injury and Repair

Stephanie M. Bersie; Alexandra L. McCubbrey

doi:10.1055/a-2675-2564

Seminars in Respiratory and Critical Care Medicine, Inhaltsverzeichnis

CC BY 4.0 · Semin Respir Crit Care Med
DOI: 10.1055/a-2675-2564

Review Article

Heterogeneity of Lung Phagocytes and Clearance of Apoptotic Cells in Lung Injury and Repair

Authors

Stephanie M. Bersie

¹Toxicology Graduate Program, University of Colorado Denver Skaggs School of Pharmacy, Aurora, Colorado
Alexandra L. McCubbrey

²Department of Medicine, National Jewish Health, Denver, Colorado

³Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado

Abstract

Poor repair following lung injury is a significant cause of morbidity and mortality. Clearance of apoptotic cells, termed efferocytosis, has emerged as a key process that can influence repair outcomes and facilitate successful repair. Although prior literature has focused on efferocytosis by macrophages, evidence is emerging that nonprofessional phagocytes, including fibroblasts and epithelial cells, may play critical roles in efferocytosis during tissue repair. This review summarizes existing knowledge of different lung phagocytes that can participate in efferocytosis, evidence linking efferocytosis to lung health and tissue repair, and discusses factors that may inhibit or redirect efferocytosis to promote mis-repair. A deeper understanding of how the integrated landscape of lung phagocytes participates in efferocytosis will likely provide significant insight into repair and mis-repair processes.

Keywords

efferocytosis - apoptotic cell clearance - lung - macrophage - nonprofessional phagocyte - repair

Volltext

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