Accelerated apixaban removal by using the ADVOS albumin hemodialysis system

Bernd Panholzer; Ulrike Nowak-Goettl; Katharina Huenges; Wiebke Sommer

doi:10.1055/a-2682-8640

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CC BY 4.0 · Thorac Cardiovasc Surg Rep
DOI: 10.1055/a-2682-8640

Case Report: Cardiac

Accelerated apixaban removal by using the ADVOS albumin hemodialysis system

Bernd Panholzer

¹Cardiac Surgery, University Hospital Schleswig-Holstein - Campus Kiel, Kiel, Germany (Ringgold ID: RIN54186)

,

Ulrike Nowak-Goettl

²Institute of Clinical Chemistry, University Hospital Schleswig-Holstein - Campus Kiel, Kiel, Germany (Ringgold ID: RIN54186)

,

Katharina Huenges

³Cardiovascular Surgery, University of Schleswig-Holstein Campus Kiel, Kiel, Germany

,

Wiebke Sommer

¹Cardiac Surgery, University Hospital Schleswig-Holstein - Campus Kiel, Kiel, Germany (Ringgold ID: RIN54186)

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Background: In patients on direct oral anticoagulants (DOAC), emergency surgery is characterized by an increased risk for bleeding. Case Description: A 72-year-old male patient with cardiogenic shock required emergency surgery due to severe aortic regurgitation resulting from acute prosthetic valve endocarditis. Due to atrial fibrillation, the patient was taking apixaban until surgery. Postoperatively, the ADVanced Organ Support (ADVOS) albumin hemodialysis system was used. Serial measurements revealed strongly accelerated apixaban removal, while drainage losses were only moderate. Conclusion: ADVOS accelerates the removal of apixaban and is a promising therapy for preventing bleeding complications in patients receiving DOAC after emergency surgery.

Publication History

Received: 01 July 2024

Accepted after revision: 02 September 2024

Accepted Manuscript online:
14 August 2025

© . The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/).

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