Synthesis, Table of Contents Synthesis DOI: 10.1055/a-2685-9083 Paper Published as part of the Special Issue in Honor of Prof. Franziska Schoenebeck, the 2025 Women in Chemistry Award Winner Desaturation of Amides via Bismuth Photocatalysis Authors Author Affiliations Byeongdo Roh 1 Department of Organometallic Chemistry, Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz, 1, 45470 Mülheim an der Ruhr, Germany Josep Cornella 1 Department of Organometallic Chemistry, Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz, 1, 45470 Mülheim an der Ruhr, Germany Recommend Article Abstract Buy Article(opens in new window) All articles of this category(opens in new window) Abstract Bismuth redox catalysis has been intensively developed in recent years, enabling diverse transformations that were previously thought to be achievable only through transition metal catalysis. In this study, we present the desaturation of amides to generate the enamides, an important structural motif in pharmaceuticals, via bismuth photocatalysis. The protocol involves a combination of unique mechanistic steps recently uncovered for bismuth thus allowing for the translation of a canonical transition metal–mediated transformation into a main group–based catalytic system. Keywords KeywordsBismuth - Low-valent bismuth - Bismuth redox catalysis - Bismuth photocatalysis - Desaturation - Amides Full Text References References 1a Flatt B, Martin R, Wang TL. et al. J Med Chem 2009; 52: 904 1b Perez-Sayans M, Somoza-Martin JM, Barros-Angueira F, Rey JMG, Garcia-Garcia A. Cancer Treat Rev 2009; 35: 707 1c Fu J, Si P, Zheng M. et al. Bioorg Med Chem Lett 2012; 22: 6848 1d Poulsen TB. Acc Chem Res 1830; 2021: 54 2a Courant T, Dagousset G, Masson G. Synthesis 2015; 47: 1799 2b Beltran F, Miesch L. Synthesis 2020; 52: 2497 2c Bouchet D, Varlet T, Masson G. 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