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Int J Angiol
DOI: 10.1055/a-2692-1606
Review Article

Predictive Value of Glycated Hemoglobin for the Severity of Coronary Artery Disease: A Study at Somalia's Largest Tertiary Care Center

Authors

  • Mohamud Mire Waberi

    1   Department of Cardiology, Mogadishu Somali-Türkiye Recep Tayyip Erdogan Training and Research Hospital, Mogadishu, Somalia

  • Said Abdirahman Ahmed

    1   Department of Cardiology, Mogadishu Somali-Türkiye Recep Tayyip Erdogan Training and Research Hospital, Mogadishu, Somalia

  • Mohamed Omar Hassan

    1   Department of Cardiology, Mogadishu Somali-Türkiye Recep Tayyip Erdogan Training and Research Hospital, Mogadishu, Somalia

  • Nur Adam Mohamed

    2   Department of Psychiatry, Mogadishu Somali-Türkiye Recep Tayyip Erdogan Training and Research Hospital, Mogadishu, Somalia

  • Feyza Aksu

    1   Department of Cardiology, Mogadishu Somali-Türkiye Recep Tayyip Erdogan Training and Research Hospital, Mogadishu, Somalia
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Abstract

Studies investigating the ability of glycated hemoglobin (HbA1c) to predict the severity of coronary artery disease (CAD) have shown inconsistent findings. While certain studies have indicated a notable connection between elevated HbA1c levels and more advanced CAD, other investigations have not discovered a significant correlation. Differences in the results may arise due to various factors, including the characteristics of the study population, the size of the sample, the study design, and methodological variations. This study aimed to investigate the correlation between HbA1c levels and the extent of CAD in individuals, including both those with diabetes and those without, who have had angiography for either acute coronary syndrome (ACS) or chronic coronary syndrome (CCS). This descriptive observational study was conducted in a hospital setting. Patients who underwent coronary angiograms between July 2022 and November 2023 participated. HbA1c level estimation was conducted on blood samples obtained from 239 patients, both diabetic and non-diabetic, who sought medical attention for ACS and CCS in the emergency and outpatient clinics. Coronary angiography was performed on all individuals. The data underwent statistical analysis and were correlated. The average age of the patients was 61 ± 12.9 years. Three groups were divided according to the number of involved vessels. Single-vessel disease (group 1) was detected in 94 patients, two-vessel disease (group 2) was detected in 75, and three-vessel disease (group 3) was detected in 70 patients. It was shown that as the number of affected vessels increased, HbA1c levels increased statistically significantly in group 1 when compared with groups 2 and 3. While there was no significant difference in age between two-vessel and three-vessel spaces, patients with single-vessel spaces were found to be younger. Although smoking was found to be low in all study patients, a significantly lower rate was found in the division with single-vessel disease (group 1 vs. group 2: p = 0.014; group 1 vs. group 3: p = 0.036; group 2 vs. group 3: p = 0.739). Hypertension (HTN), diabetes mellitus (DM), and dyslipidemia were similar in all three groups. According to our study's research, the correlation between HbA1c and the severity of CAD seems to have meaningful statistical value. We discovered that the number of vessels impacted by ischemia increased in parallel with the level of HbA1c. Nevertheless, it is crucial to consider other variables that could impact the severity of CAD, carry out additional investigations to authenticate these results, and investigate additional potential predictors.

Keywords

glycated hemoglobin - coronary artery disease - diabetic mellitus - angiography

Contributors' Statement

All authors made significant contributions to the work reported, whether that is in the conception, study design, execution, acquisition of data, analysis and interpretation, or in all these areas; took part in drafting, revising, or critically reviewing the article; gave final approval of the version to be published; have agreed on the journal to which the article has been submitted; and agreed to be accountable for all aspects of the work.


Ethical Approval

The ethical committee of the Mogadishu Somali Turkish Training and Research Hospital assessed and approved the study, assigning it the ethical protocol number MSTH/15790. As our hospital functions as a research and training facility, prior to admission, each patient or caregiver is provided with informed consent to utilize their data for research purposes while ensuring their names remain undisclosed. Furthermore, our hospital's guidelines state that retrospective studies do not require informed consent as long as patient data remain confidential. The study adheres to the principles outlined in the Declaration of Helsinki, and this research did not receive any dedicated financial support.




Publikationsverlauf

Eingereicht: 02. Januar 2025

Angenommen: 06. August 2025

Artikel online veröffentlicht:
22. September 2025

© 2025. International College of Angiology. This article is published by Thieme.

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