This personal account is primarily focused on various functionalization tools for
quinoxaline moiety. This bicyclic heterocycle is widespread in natural products, pharmaceutical
drugs, agrochemicals and is also one of the core motifs for material science application.
Transition metals can induce various reactivity in this benzopyrazine ring viz., C3H
functionalization, annulation, spirocyclization, bis-functionalization across C=N
bond, etc. Such functionalization enhances the biological activity of the core, thereby
underscoring the importance of various synthetic processes. Our group has been actively
engaged in developing new sustainable synthetic approaches for the functionalization
of quinoxaline using thermal or green energy in the form of visible-light or solar
energy. This review summarizes the various synthetic methodologies developed in our
laboratory in order to functionalize the quinoxaline moiety.
