Neue Sicherheitsdaten zu JAK-Inhibitoren bei rheumatoider Arthritis

Zusammenfassung

Während die Wirksamkeit von Januskinase-Inhibitoren (JAKi) für die Behandlung der rheumatoiden Arthritis (RA) unumstritten ist, gibt es weitreichende Diskussionen bezüglich ihrer Sicherheit. Risiken hinsichtlich des Auftretens kardiovaskulärer und thromboembolischer Ereignisse, schwerer Infektionen und Krebserkrankungen wurden in umfangreichen Analysen mit Daten aus klinischen Studien, aber insbesondere in prospektiv angelegten RA-Registern untersucht. In dieser Arbeit geben wir einen Überblick über die neuesten Daten zur Sicherheit von JAKi für Patienten mit RA und fassen die derzeitigen Empfehlungen zusammen.

Abstract

While the efficacy of Janus kinase inhibitors (JAKi) for the treatment of rheumatoid arthritis (RA) is undisputed, there is widespread debate regarding their safety. Risks related to the occurrence of cardiovascular and thromboembolic events, serious infections, and malignancies have been investigated in extensive analyses, using data from clinical trials, and, in particular, in prospective RA registers. This paper provides an overview of the latest safety data for JAKi in patients with RA and summarises the current recommendations.

Schlüsselwörter

tsDMARDs - kardiovaskuläre Ereignisse - thromboembolische Ereignisse - Infektionen - Malignome

Keywords

tsDMARDs - cardiovascular events - thromboembolic events - serious infections - malignancies

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