Severe phytophotodermatitis caused by mulberry tree: A case report and literature review

Phytophotodermatitis (PDD) is an uncommon dermatologic condition that occurs after exposure to furocoumarins found in certain plant saps, which become activated upon ultraviolet A radiation exposure. This condition is frequently misdiagnosed as cellulitis, allergic dermatitis, or other common skin disorders. Here, we present a case of severe phytophotodermatitis in a 52-year-old male who initially developed a rash and blistering on his forearm following outdoor activity. He was initially misdiagnosed with cellulitis; however, his symptoms persisted despite antibiotic treatment, prompting further evaluation. A detailed patient history revealed recent contact with a mulberry tree, and together with characteristic biopsy findings, this confirmed the diagnosis of phytophotodermatitis. The patient showed significant improvement following the administration of oral corticosteroids and topical steroid treatment. This case underscores the importance of recognizing phytophotodermatitis in clinical practice to prevent misdiagnosis and ensure effective management.

Publication History

Received: 17 March 2025

Accepted after revision: 09 September 2025

Accepted Manuscript online:
12 September 2025