Interhemispheric–Transcortical Approach for Resection of an Atypical Teratoid/Rhabdoid Tumor (AT/RT) of the Left Lateral and Third Ventricle

Abstract

Introduction

Atypical teratoid/rhabdoid tumors (AT/RT) are malignant central nervous system (CNS) tumors that represent 3% of all pediatric CNS tumors. Majority of cases have SMARCB1 gene mutations and historically carried a poor prognosis.

Case Presentation

A 9-year-old boy was diagnosed with a third ventricle AT/RT and initially underwent endoscopic surgical biopsy. Subsequent tumor resection was completed using an interhemispheric–transcortical approach.

Lessons

Surgical approaches to ventricular system must be tailored to the tumor characteristics on a case-by-case basis. We present a case using a transcortical approach for understanding of the microsurgical anatomy for safe resection of a third ventricle AT/RT.

Keywords

AT/RT - atypical teratoid/rhabdoid tumor - ventricular surgery - pediatric neuro-oncology - high-grade glioma

Publication History

Received: 18 June 2025

Accepted: 24 June 2025

Article published online:
30 September 2025

• References

• 1 Ahmed SI, Javed G, Laghari AA. et al. Third ventricular tumors: a comprehensive literature review. Cureus 2018; 10 (10) e3417
• 2 Elwatidy SM, Albakr AA, Al Towim AA, Malik SH. Tumors of the lateral and third ventricle: surgical management and outcome analysis in 42 cases. Neurosciences (Riyadh) 2017; 22 (04) 274-281
• 3 Cikla U, Swanson KI, Tumturk A. et al. Microsurgical resection of tumors of the lateral and third ventricles: operative corridors for difficult-to-reach lesions. J Neurooncol 2016; 130 (02) 331-340
• 4 Sherrod BA, Iyer RR, Kestle JRW. Endoscopic third ventriculostomy for pediatric tumor-associated hydrocephalus. Neurosurg Focus 2020; 48 (01) E5
• 5 Alva E, Rubens J, Chi S. et al. Recent progress and novel approaches to treating atypical teratoid rhabdoid tumor. Neoplasia 2023; 37: 100880