The 1,2-dicarbonyls are excellent moieties in organic synthesis and they offer scope
for the synthesis of numerous interesting heterocycles. Likewise, the alkynes are
widespread in nature and drugs. Herein, the present article highlights the application
of alkynes in organic synthesis as 1,2-dicarbonyl surrogates by I2/DMSO and NIS/DMSO
mediated oxidations through a cascade of iodination and Kornblum oxidation. These
approaches are mild, efficient, and tolerate many functional groups. The NIS/DMSO,
and iodine-DMSO mediated oxidation of alkynes to 1,2-dicarbonyl compounds and trapping
by several nucleophiles to construct important diversely functionalized heterocycles
have been discussed in this article. The state of art, challenges, and future perspective
have been highlighted in the present collection.
