Total Synthesis of Vestitol and Medicarpin

Jigang Gao; Qiling Chen; Shaobin Su; Bin Cheng; Hongjian Yang; Haiyan Sun

doi:10.1055/a-2705-4229

Synthesis, Inhaltsverzeichnis

Synthesis
DOI: 10.1055/a-2705-4229

Paper

Total Synthesis of Vestitol and Medicarpin

Authors

Jigang Gao

¹School of Food and Drug, Shenzhen Polytechnic University, Shenzhen, China (Ringgold ID: RIN47891)

²Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China (Ringgold ID: RIN12381)
Qiling Chen

¹School of Food and Drug, Shenzhen Polytechnic University, Shenzhen, China (Ringgold ID: RIN47891)
Shaobin Su

³Chemistry Department, Foshan Ionova Biotherapeutics Co., Inc., Foshan, China
Bin Cheng

¹School of Food and Drug, Shenzhen Polytechnic University, Shenzhen, China (Ringgold ID: RIN47891)
Hongjian Yang

³Chemistry Department, Foshan Ionova Biotherapeutics Co., Inc., Foshan, China
Haiyan Sun

¹School of Food and Drug, Shenzhen Polytechnic University, Shenzhen, China (Ringgold ID: RIN47891)

Abstract

Alle Artikel dieser Rubrik

Abstract

Total synthesis of vestitol and medicarpin, two isoflavonoids with distinct skeletons, was successfully achieved using a single intermediate as the starting point. This six-step synthetic approach features a BBr₃-promoted tandem O-demethylation/cyclization reaction, which enables the rapid construction of the pterocarpan core structure. Subsequently, a Pd/C-catalyzed hydrogenation/hydrogenolysis reaction was employed to respectively synthesize vestitol and medicarpin.

Keywords

Total synthesis - Isoflavonoid - Medicarpin - Vestitol - Hydrogenation

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Referenzen

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