Expedient Route to Access C8-Carbonylated Quinolines via Photo-Induced C(sp³)–H Oxidation

Santu Mandal; Saikat Bera; Bijoy Debnath; Pallabi Paul; Tharmalingam Punniyamurthy

doi:10.1055/a-2708-6984

Synthesis, Inhaltsverzeichnis

Synthesis
DOI: 10.1055/a-2708-6984

Feature

Expedient Route to Access C8-Carbonylated Quinolines via Photo-Induced C(sp³)–H Oxidation

Authors

Santu Mandal

¹Chemistry, IIT Guwahati, Guwahati, India (Ringgold ID: RIN28678)
Saikat Bera

¹Chemistry, IIT Guwahati, Guwahati, India (Ringgold ID: RIN28678)
Bijoy Debnath

¹Chemistry, IIT Guwahati, Guwahati, India (Ringgold ID: RIN28678)
Pallabi Paul

¹Chemistry, IIT Guwahati, Guwahati, India (Ringgold ID: RIN28678)
Tharmalingam Punniyamurthy

¹Chemistry, IIT Guwahati, Guwahati, India (Ringgold ID: RIN28678)

Abstract

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Visible light enabled C(sp3)-H oxidation of 8-alkylquinolines has been accomplished utilizing [Mes-Acr-Me]BF4 under air. The reaction offers an effective synthetic approach to direct access C8-carbonyl quinolines bearing aldehydes, ketones and esters groups and allows other important functional handle through Post-synthetic modification. The site-selective C(sp3)-H oxidation, use of air as oxidant, substrate scope and post-synthetic potential are the salient practical features.

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