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Synthesis
DOI: 10.1055/a-2708-6984
Feature

Expedient Route to Access C8-Carbonylated Quinolines via Photo-Induced C(sp³)–H Oxidation

Authors

  • Santu Mandal

    1   Chemistry, IIT Guwahati, Guwahati, India (Ringgold ID: RIN28678)

  • Saikat Bera

    1   Chemistry, IIT Guwahati, Guwahati, India (Ringgold ID: RIN28678)

  • Bijoy Debnath

    1   Chemistry, IIT Guwahati, Guwahati, India (Ringgold ID: RIN28678)

  • Pallabi Paul

    1   Chemistry, IIT Guwahati, Guwahati, India (Ringgold ID: RIN28678)

  • Tharmalingam Punniyamurthy

    1   Chemistry, IIT Guwahati, Guwahati, India (Ringgold ID: RIN28678)

Supported by: Science and Engineering Research Board (JCB/2022/000037; SCP/2022/000256 and CRG/2022/002
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Visible light enabled C(sp3)-H oxidation of 8-alkylquinolines has been accomplished utilizing [Mes-Acr-Me]BF4 under air. The reaction offers an effective synthetic approach to direct access C8-carbonyl quinolines bearing aldehydes, ketones and esters groups and allows other important functional handle through Post-synthetic modification. The site-selective C(sp3)-H oxidation, use of air as oxidant, substrate scope and post-synthetic potential are the salient practical features.



Publication History

Received: 04 August 2025

Accepted after revision: 24 September 2025

Accepted Manuscript online:
24 September 2025

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