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DOI: 10.1055/a-2712-9192
Idiopathischer Chylothorax bei Hund und Katze
Anatomische Grundlagen, Pathogenese und TherapieoptionenIdiopathic chylothorax in dogs and catsAnatomical foundations, pathogenesis, and therapeutic optionsAuthors
Zusammenfassung
Der idiopathische Chylothorax ist eine seltene Erkrankung beim Kleintier mit weitgehend unklarer Ätiologie. Beim Hund konnten mittlerweile in mehreren Studien hohe Erfolgsraten nach chirurgischer Behandlung erzielt werden, die Prognose bei der Katze bleibt dagegen weiterhin ungünstig. Ziel dieses Artikels ist es, ein integratives Verständnis der Erkrankung zu entwickeln, das anatomische, pathophysiologische, physikalische und klinische Aspekte systematisch verknüpft. Die verfügbaren konservativen und chirurgischen Verfahren werden im Hinblick auf Erfolgsraten, Komplikationen und prognostische Relevanz eingeordnet. Dabei wird herausgearbeitet, welche therapeutischen Entscheidungen sich trotz begrenzter Datenlage in der Praxis begründen lassen – und welche Annahmen kritisch zu hinterfragen sind. So erscheint insbesondere ein verzögerter Operationszeitpunkt als potenziell nachteiliger Aspekt im derzeitigen Behandlungskonzept. Auch die bislang standardisierte Wahl einer weit kaudalen Ligatur des Ductus thoracicus wird im Licht anatomisch-pathophysiologischer Kenntnisse diskutiert. Die derzeitige Studienlage erlaubt zudem keine klare Indikationsstellung für eine Ablation der Cisterna chyli; auch zur Rolle der Perikardektomie bestehen in der neueren Literatur unterschiedliche Einschätzungen. Aus den dargestellten Beobachtungen ergeben sich konkrete Impulse für weiterführende Forschung und eine differenziertere klinische Entscheidungsfindung.
Abstract
Idiopathic chylothorax is a rare condition in small animals with a largely unknown etiology. In dogs, several recent studies have reported high surgical success rates, whereas the prognosis in cats remains unfavorable. The aim of this article is to develop an integrative understanding of the disease by systematically integrating anatomical, pathophysiological, physical, and clinical perspectives. Available conservative and surgical treatment strategies are evaluated with regard to success rates, complications, and prognostic relevance. Particular emphasis is placed on identifying which therapeutic decisions can be reasonably supported in clinical practice despite limited evidence and which prevailing assumptions warrant critical reassessment. A delayed surgical approach, in particular, appears to represent a potential negative aspect in current treatment concepts. The commonly standardized practice of performing thoracic duct ligation at a caudal thoracic level is also reconsidered in light of anatomical and pathophysiological findings. Furthermore, the current literature provides no clear recommendation regarding the indication for cisterna chyli ablation, and there is increasing divergence of opinion on the role of pericardectomy. The insights presented here generate concrete impulses for further research and support a more differentiated basis for clinical decision-making.
Schlüsselwörter
Kleintier - Ductus thoracicus - Cisterna chyli - Perikardektomie - Pathophysiologie - Chirurgische TherapieKeywords
Small animal - thoracic duct - cisterna chyli - pericardectomy - pathophysiology - surgical treatmentPublication History
Received: 27 May 2025
Accepted: 24 October 2025
Article published online:
28 November 2025
© 2025. Thieme. All rights reserved.
Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany
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Literatur
- 1 Fossum TW, Birchard SJ, Jacobs RM. Chylothorax in 34 dogs. J Am Vet Med Assoc 1986; 188: 1315-1318
- 2 Fossum TW. (Hrsg.), Chirurgie der Kleintiere. 5. Aufl. Stuttgart: Elsevier; 2021: 1060-1068
- 3 König HE, Liebich HG. Anatomie der Haussäugetiere. Lehrbuch und Farbatlas für Studium und Praxis. 8. Aufl. Stuttgart: Thieme; 2024: 507-508
- 4 Nickel R, Schummer A, Seiferle E. Lehrbuch der Anatomie der Haustiere. Band 3. 2. Aufl.. Berlin: Parey; 1983: 302-376
- 5 Chiang C, Chen KS, Chiu H. et al. Computed tomography lymphangiography via intrametatarsal pad injection is feasible in cats with chylothorax. Am J Vet Res 2021; 83: 133-139
- 6 Eken E, Bahar S, Gezici M. Thoracic duct in cats (Felis catus). Rev Méd Vét 2002; 153: 717-721
- 7 Liebich HG. Funktionelle Histologie der Haussäugetiere und Vögel. 5. Aufl. Stuttgart: Thieme; 2010. 142.
- 8 Banks WJ. Applied Veterinary Histology. 2. Auflage. Baltimore: Williams & Wilkins; 1986. 329.
- 9 American College of Veterinary Surgeons (ACVS). Chylothorax in Small Animals. Im Internet https://www.acvs.org/small-animal/chylothorax/ [Stand: 20.04.2025]
- 10 Nelson RW, Couto CG. Small Animal Internal Medicine. 6. Auflage.. St. Louis: Elsevier; 2022: 361-362
- 11 Tobias KM, Johnston SA. Veterinary Surgery: Small Animal. 2. Auflage. St. Louis: Elsevier; 2012. 1793 und 1803-1807
- 12 Singh A, Brisson B, Nykamp S. Idiopathic Chylothorax: Pathophysiology, Diagnosis, and Thoracic Duct Imaging. Compend Contin Educ Vet 2012; 34: E2
- 13 McGavin MD, Zachary JF. Pathologie der Haustiere. 5. Aufl. Stuttgart: Elsevier; 2009. 569.
- 14 Fossum TW, Birchard SJ, Forrester SD. et al. Chylothorax in cats: 37 cases (1969–1989). J Am Vet Med Assoc 1991; 672-678
- 15 Birchard SJ, Ware WA, Fossum TW. et al. Chylothorax associated with congestive cardiomyopathy in a cat. J Am Vet Med Assoc 1986; 189: 1462-1464
- 16 McLane MJ, Buote NJ. Lung lobe torsion associated with chylothorax in a cat. J Feline Med Surg 2011; 13: 135-138
- 17 Salomon F, Geyer H, Gille U. Anatomie für die Tiermedizin. 4. Aufl. Stuttgart: Enke; 2020. 464.
- 18 Hodges CC, Fossum TW, Evering W. Evaluation of thoracic duct healing after experimental laceration and transection in dogs. Vet Surg 1993; 22: 431-435
- 19 Lama A, Ferreiro L, Toubes M. et al. Characteristics of patients with pseudochylothorax – a systematic review. J Thorac Dis 2016; 8: 2093-2101
- 20 Lin CH, Lo PY, Lam MC. et al. Usefulness of Chest Ultrasonography in Predicting Diagnosis in Non-emergency Small Animal Patients With Lung Parenchymal and Pleural Disease. Front Vet Sci 2020; 7: 616882
- 21 American Heartworm Society. Canine Guidelines for the Prevention, Diagnosis, and Management of Heartworm (Dirofilaria immitis) Infection in Dogs. 2018. Im Internet: https://www.heartwormsociety.org/images/pdf/2018-AHS-Canine-Guidelines.pdf [Stand 30.09.2025]
- 22 Little S, Levy J, Hartmann K. et al. Feline Retrovirus Testing and Management Guidelines. J Feline Med Surg 2020; 22: 5-30
- 23 Lin LS, Chiu HC, Nishimura R. et al. Computed tomography via intra-metatarsal pad injection is feasible in dogs with chylothorax. Vet Radiol Ultrasound 2020; 61: 435-443
- 24 Singh A, Brisson B, Nykamp S. Idiopathic Chylothorax in Dogs and Cats: Nonsurgical and Surgical Management. Compend Contin Educ Vet 2012; 34: E3
- 25 Sturgess K. Diagnosis and management of chylothorax in dogs and cats. In Practice 2001; 23: 506-513
- 26 Thompson M, Cohn LA, Jordan RC. Use of rutin for medical management of idiopathic chylothorax in four cats. J Am Vet Med Assoc 1999; 215: 345-348
- 27 Kopko SH. The use of rutin in a cat with idiopathic chylothorax. Can Vet J 2005; 46: 729-731
- 28 Yang YH, Park SY, Kim DJ. et al. Chyle Leakage after Esophageal Cancer Surgery. Korean J Thorac Cardiovasc Surg 2020; 53: 191-199
- 29 Birchard SJ, Smeak DD, McLoughlin MA. Chylothorax in the dog and cat: a review Lymphology. 1995; 28: 64-72
- 30 McAnulty JF. Prospective Comparison of Cisterna Chyli Ablation to Pericardectomy for Treatment of Spontaneously Occurring Idiopathic Chylothorax in the Dog. Vet Surg 2011; 40: 926-934
- 31 Reeves L, Anderson KM, Luther J. et al. Treatment of Idiopathic Chylothorax in dogs and cats: a systematic review. Vet Surg 2020; 49: 70-79
- 32 Greenberg MJ, Weisse CW. Spontaneous resolution of iatrogenic chylothorax in a cat. J Am Vet Med Assoc 2005; 226: 1667-1670
- 33 Willard MD, Fossum TW, Torrance A. et al Hyponatremia and hyperkalemia associated with idiopathic or experimentally induced chylothorax in four dogs. J Am Vet Med Assoc 1991; 199: 353-358
- 34 Allman DA, Radlinsky mg, Ralph AG. et al. Thoracoscopic thoracic duct ligation and thoracoscopic pericardectomy for treatment of chylothorax in dogs. Vet Surg 2010; 39: 21-27
- 35 Martin RA, Richards DL, Barber DL. et al. Transdiaphragmatic approach to thoracic duct ligation in the cat. Vet Surg 1988; 27: 22-26
- 36 Enwiller TM, Radlinsky mg, Mason DE, Roush JK. Popliteal and mesenteric lymph node injection with methylene blue for coloration of the thoracic duct in dogs. Vet Surg 2003; 32: 350-364
- 37 Birchard SJ, Fossum TW. Chylothorax in the dog and cat. Vet Clin North Am Small Anim Pract 1987; 17: 271-283
- 38 Fossum TW, Mertens MM, Miller MW. et al. Thoracic duct ligation and pericardectomy for treatment of idiopathic chylothorax. J Vet Intern Med 2004; 18: 307-310
- 39 Dickson R, Adam A, Garcia Rubio D. et al. Outcome of video-assisted thoracoscopic treatment of idiopathic chylothorax in 15 cats. Vet Surg 2024; 53: 852-859
- 40 Mayhew PD, Balsa IM, Stern JA. et al. Resolution, recurrence, and chyle redistribution after thoracic duct ligation with or without pericardiectomy in dogs with naturally occurring idiopathic chylothorax. J Am Vet Med Assoc 2022; 261: 696-704
- 41 Kanai H, Furuya M, Hagiwara K. et al. Efficacy of en bloc thoracic duct ligation in combination with pericardectomy by video-assisted thoracoscopic surgery for canine idiopathic chylothorax. Vet Surg 2020; 49: 102-111
- 42 Mayhew PD, Steffey MA, Fransson BA. et al. Long-term outcome of video-assisted thoracoscopic thoracic duct ligation and pericardectomy in dogs with chylothorax: a multi-institutional study of 39 cases. Vet Surg 2019; 48: 112-120
- 43 Sicard GK, Waller KR, McAnulty J. The effect of cisterna chyli ablation combined with thoracic duct ligation on abdominal lymphatic drainage. Vet Surg 2005; 34: 64-70
- 44 Hayashi K, Sicard G, Gellasch K. et al. Cisterna chyli ablation with thoracic duct ligation for chylothorax: results in eight dogs. Vet Surg 2005; 34: 519-523
- 45 Stockdale SL, Gazzola KM, Strouse JB. et al. Comparison of thoracic duct ligation plus subphrenic pericardiectomy with or without cisterna chyli ablation for treatment of idiopathic chylothorax in cats. J Am Vet Med Assoc 2018; 252: 976-981
- 46 How CH, Hsu HH, Chen JS. Chemical pleurodesis for spontaneous pneumothorax. J Formos Med Assoc 2013; 112: 749-755
- 47 Stewart TA, Weisse C, Solomon JA. Chylothorax treated via thoracic duct ligation and omentalization. J Am Anim Hosp Assoc 2010; 46: 312-317
- 48 Bussadori R, Provera A, Martano M. et al. Pleural omentalisation with en bloc ligation of the thoracic duct and pericardiectomy for idiopathic chylothorax in nine dogs and four cats. Vet J 2011; 188: 234-236
- 49 Weisse C, Berent A. Veterinary Image-Guided Interventions. Wiley Blackwell; 2015. Kapitel 50: Cisterna chyli and thoracic duct glue embolization 497-502
- 50 Pardo AD, Bright RM, Walker MA. et al. Transcatheter thoracic duct embolization in the dog: an experimental study. Vet Surg 1989; 18: 279-285
- 51 Carvajal J, Case JB, Grosso FRV. et al. Prospective evaluation of lymphatic embolization as part of the treatment in dogs with presumptive idiopathic chylothorax. Vet Surg 2022; 51: 128-137
- 52 Jackson J, Richter KP, Launer DP. Thoracoscopic partial pericardiectomy in 13 dogs. J Vet Intern Med 1999; 13: 529-533
- 53 Kesieme EB, Dongo A, Ezemba N. et al. Tube thoracostomy: complications and its management. Pulm Med 2012; 256878
- 54 Tattersall JA, Welsh E. Factors influencing the short-term outcome following thoracic surgery in 98 dogs. J Small Anim Pract 2006; 47: 715-720
- 55 Théron ml, Lahuerta-Smith T, Sarrau S. et al. Autologous blood patch pleurodesis treatment for persistent pneumothorax: a case series of five dogs (2016–2020). Open Vet J 2021; 11: 289-294
- 56 Hatch A, Jandrey KE, Tenwolde MC, Kent MS. Incidence of chyloabdomen diagnosis in dogs and cats and corresponding clinical signs, clinicopathologic test results, and outcomes: 53 cases (1984-2014). J Am Vet Med Assoc 2018; 253: 886-892
- 57 D'Agostino HP, Edens MA. Physiology, pleural fluid. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2025. Im Internet https://www.ncbi.nlm.nih.gov/books/NBK513353/ [Stand 29.09.2025]
- 58 Ross BB, Gramiak R, Rahn H. Physical dynamics of the cough mechanism. J Appl Physiol 1955; 8: 264-268
- 59 Mohanakrishnan BPE, Tasnim S, Vo T. et al. “Coughing chylothorax”: traumatic noniatrogenic thoracic duct leak. J Thorac Cardiovasc Surg 2022; A78: 162
- 60 Anger M, Hofmann J, Ruf B. et al. Cough-induced chylothorax in a two-year-old boy - case report and review of the literature. BMC Pediatr 2023; 23: 416
- 61 Korpes K, Kolenc M, Vukicevic TT. et al. Anatomical variations of the thoracic duct in the dog. Anat Histol Embryol 2021; 50: 1015-1025
- 62 Pang CY. Autonomic control of the venous system in health an disease: effects of drugs. Pharmacol Ther 2001; 90: 179-230
- 63 Price J, Mathews KG, Lawver JW. et al. Evaluation of thoracic duct ligation and unilateral subphrenic pericardectomy via a left fourth intercostal approach in normal canine cadavers. Vet Surg 2024; 53: 437-446
- 64 Price AK, Mathews KG. A single left fourth intercostal thoracotomy approach for resolution of idiopathic chylothorax with thoracic duct ligation and pericardiectomy: a preliminary clinical study in two dogs. Front Vet Sci 2024; 4: 1463939
- 65 Steffey MA, Mayhew PD. Use of direct near-infrared fluorescent lymphography for thoracoscopic thoracic duct identification in 15 dogs with chylothorax. Vet Surg 2018; 47: 267-276
