Subscribe to RSS
DOI: 10.1055/a-2713-6326
Out of the Past: A Case Report of Left Ventricle Free Wall Rupture
Authors

Abstract
Left ventricular free wall rupture (LVFWR) is a now exceedingly rare, but potentially life-threatening complication of myocardial infarction (MI) that can present as cardiac tamponade and/or cardiogenic shock. Seen more commonly in days prior to reperfusion as a sequela of complicated transmural MI, LVFWR has seen a decline in incidence in the age of primary angioplasty for MI. It is now a rarely encountered phenomenon usually associated with late-presenting MI. We present a case of LVFWR following a late-presenting MI with severe shock and cardiac tamponade. Initial transthoracic echocardiography with contrast showed pericardial effusion with cardiac tamponade and no overt signs of rupture. Computed tomography angiography of the chest and Transesophageal echocardiography did not demonstrate aortic dissection. Pericardiocentesis of hemorrhagic effusion transiently improved hemodynamics but was followed by rapid cardiac decline and death. Subsequent necropsy showed left ventricular wall rupture with focal fibrosis in the distal left ventricular wall, consistent with a remote infarction, along with a large pericardial clot. This case underscores the diagnostic challenges of LVFWR, particularly when imaging is inconclusive in hemodynamically unstable patients. Despite technological advances, clinical suspicion remains paramount, especially in patients presenting with shock and hemorrhagic pericardial effusion. Surgical intervention remains the definitive therapy.
Keywords
hemorrhagic pericardial effusion - cardiac tamponade - free wall rupture - aortic dissection - cardiogenic shock - case reportContributor's Statement
L.K. and K.S. were responsible for the original draft preparation and writing. F.K. provided supervision, while M.R. contributed to both supervision and the reviewing and editing of the manuscript.
Informed Consent
Informed consent was obtained from the patient in accordance with COPE guidelines.
Publication History
Received: 24 July 2025
Accepted: 29 September 2025
Article published online:
19 October 2025
© 2025. International College of Angiology. This article is published by Thieme.
Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA
-
References
- 1 Honda S, Asaumi Y, Yamane T. et al. Trends in the clinical and pathological characteristics of cardiac rupture in patients with acute myocardial infarction over 35 years. J Am Heart Assoc 2014; 3 (05) e000984
- 2 López-Sendón J, Gurfinkel EP, Lopez de Sa E. et al; Global Registry of Acute Coronary Events (GRACE) Investigators. Factors related to heart rupture in acute coronary syndromes in the Global Registry of Acute Coronary Events. Eur Heart J 2010; 31 (12) 1449-1456
- 3 Zhang RS, Ro R, Bamira D. et al. Echocardiography in the recognition and management of mechanical complications of acute myocardial infarction. Curr Cardiol Rep 2024; 26 (05) 393-404
- 4 De Lazzari M, Cipriani A, Cecere A. et al. Cardiac rupture in acute myocardial infarction: a cardiac magnetic resonance study. Eur Heart J Cardiovasc Imaging 2023; 24 (11) 1491-1500
- 5 Figueras J, Alcalde O, Barrabés JA. et al. Changes in hospital mortality rates in 425 patients with acute ST-elevation myocardial infarction and cardiac rupture over a 30-year period. Circulation 2008; 118 (25) 2783-2789
- 6 French JK, Hellkamp AS, Armstrong PW. et al. Mechanical complications after percutaneous coronary intervention in ST-elevation myocardial infarction (from APEX-AMI). Am J Cardiol 2010; 105 (01) 59-63
- 7 Yip HK, Wu CJ, Chang HW. et al. Cardiac rupture complicating acute myocardial infarction in the direct percutaneous coronary intervention reperfusion era. Chest 2003; 124 (02) 565-571
- 8 Moreno R, López de Sá E, López-Sendón JL. et al. Frequency of left ventricular free-wall rupture in patients with acute myocardial infarction treated with primary angioplasty. Am J Cardiol 2000; 85 (06) 757-760 , A8
- 9 Nozoe M, Sakamoto T, Taguchi E, Miyamoto S, Fukunaga T, Nakao K. Clinical manifestation of early phase left ventricular rupture complicating acute myocardial infarction in the primary PCI era. J Cardiol 2014; 63 (01) 14-18
- 10 Nishiyama K, Okino S, Andou J, Nakagawa Y, Kimura T, Nobuyoshi M. Coronary angioplasty reduces free wall rupture and improves mortality and morbidity of acute myocardial infarction. J Invasive Cardiol 2004; 16 (10) 554-558
- 11 Bueno H, Martínez-Sellés M, Pérez-David E, López-Palop R. Effect of thrombolytic therapy on the risk of cardiac rupture and mortality in older patients with first acute myocardial infarction. Eur Heart J 2005; 26 (17) 1705-1711
- 12 Figueras J, Cortadellas J, Soler-Soler J. Left ventricular free wall rupture: clinical presentation and management. Heart 2000; 83 (05) 499-504
- 13 López-Sendón J, González A, López de Sá E. et al. Diagnosis of subacute ventricular wall rupture after acute myocardial infarction: sensitivity and specificity of clinical, hemodynamic and echocardiographic criteria. J Am Coll Cardiol 1992; 19 (06) 1145-1153
- 14 Matteucci M, Fina D, Jiritano F. et al. Treatment strategies for post-infarction left ventricular free-wall rupture. Eur Heart J Acute Cardiovasc Care 2019; 8 (04) 379-387
- 15 Matteucci M, Kowalewski M, De Bonis M. et al. Surgical treatment of post-infarction left ventricular free-wall rupture: a multicenter study. Ann Thorac Surg 2021; 112 (04) 1186-1192
- 16 Formica F, Mariani S, Singh G. et al. Postinfarction left ventricular free wall rupture: a 17-year single-centre experience. Eur J Cardiothorac Surg 2018; 53 (01) 150-156