The work presents a moderate, environmentally friendly process for the effective synthesis
of 2H-pyran-5-carboxlate derivatives with the use of ultrasound. High yields were
obtained in less time using the improved reaction than with conventional techniques.
The compounds have been studied by elemental analysis, mass spectroscopy, 1 H NMR,
13 C NMR, and infrared spectroscopy. When evaluated against a variety of bacterial
and fungal species, their antimicrobial activity produced encouraging findings. Furthermore,
acceptable pharmacokinetic features for several derivatives were found using ADME
profiling and drug-likeness evaluation, indicating good oral bioavailability. Together
with their antibacterial activity and good druglikeness, these compounds are intriguing
prospects for additional research as antimicrobial agents due to their green manufacturing
process.
