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DOI: 10.1055/s-0028-1086000
© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York
Disappearance of a GH Secreting Macroadenoma, during Long-term Somatostatin Analogue Administration
Publication History
received 19.01.2008
first decision 11.04.2008
accepted 14.08.2008
Publication Date:
07 October 2008 (online)
Abstract
Acromegaly is caused by excessive growth hormone secretion, usually from a pituitary adenoma. Increased mortality rate is reverted to that of the normal population after decreasing GH and IGF-I levels to less than 2–2.5 μg/liter and normal sex- and age-matched controls, respectively, regardless of the treatment employed. The use of somatostatin analogues as primary or adjunctive therapy has been widely applied in the management of acromegaly. A few cases have been reported in the literature, complete shrinkage of a pituitary GH secreting macroadenoma after long-term somatostatin analogue administration. We report a patient in whom long term (60 months) octreotide-L.A.R administration resulted in complete disappearance of a growth hormone secreting pituitary macroadenoma.
Key words
acromegaly - adenoma - disappearance - pituitary - somatostatin analogue
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Correspondence
M. ErdoganMD
Endocrinology and Metabolism Disease
Ege University Medical School
35100 Izmir
Turkey
Phone: 90/532/713 83 19
Fax: 90/232/373 77 01
Email: drmerdogan61@yahoo.com